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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2024-11-22 1:53 |
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Conference: Bucharest University Faculty of Physics 2013 Meeting
Section: Biophysics; Medical Physics
Title:
Stability studies of Promethazine hydrochloride exposed to 266 nm laser beam
Authors:
Agota Simon (1,2), Adriana Smarandache (1), Tatiana Alexandru (1,2), Viorel Nastasa (1), Mihail Lucian Pascu (1,2)
Affiliation:
(1) Laser Department, National Institute for Laser, Plasma and Radiation Physics, 077125, Magurele/Ilfov, Romania
(2) Faculty of Physics, University of Bucharest, 077125, Magurele/Ilfov, Romania
E-mail
agota.simon@inflpr.ro
Keywords:
Promethazine hydrochloride, stability studies, Nd:YAG laser
Abstract:
Promethazine hydrochloride (PMZ), a phenothiazine derivative, is a medicine which has a very strong antiemetic effect beeing also used for its antihistaminic effect [1,2].
In the present work, PMZ has been studied using spectrophotometry, laser induced fluorescence (LIF) and Fourier Transform Infrared Spectroscopy (FTIR) measurements. PMZ, dissolved in ultrapure water, was utilized for the stability analysis by observing the evolution of the absorption spectra using different concentrations in the range: 10-5M - 10-3M. The absorption spectra were investigated in three different conditions:
samples kept at room temperature and exposed to white light;
samples kept at room temperature in the dark;
samples kept between 2 and 5 0C (i.e. in the fridge) in the dark. After stability experiments, PMZ at a concentration of 20 mg/mL was irradiated using the 4th harmonic (266 nm) of a Nd:YAG laser beam. PMZ, is a photosensitive compound, so that when it is exposed to white light or to UV radiation, it will be modified at molecular level. This modification consists in the degradation of the initial (parental) compound leading to new photoproducts. To speed up this process, a high energy light beam is utilized emitted by a laser. Another advantage of using a laser beam is the specific wavelength of the radiation [3,4]. The PMZ solutions were exposed for 1, 4, 7, 10, 15, 30, 60, 120 and 240 minutes. For each of these time intervals, an unirradiated sample was kept as controle. The irradiated samples were studied using the methods of analysis mentioned above. Acknowledgements: The authors from NILPRP acknowledge the financing of the research by Program LAPLAS 3, PN 09 39/2009 and CNCS – UEFISCDI by project number PN-II-ID-PCE-2011-3-0922 and PN-II-PT-PCCA-2011-3.1-1350. Authors would like also to acknowledge the COST MP1106 network.
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