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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2024-11-24 21:14 |
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Conference: Bucharest University Faculty of Physics 2010 Meeting
Section: Optics, Spectroscopy, Plasma and Lasers
Title:
Comparative studies on laser induced Raman spectra on ultra-pure water and DMSO
Authors:
M. Boni, V. Nastasa, Angela Staicu ,I. Jepu, C. P. Lungu, A. Pascu, M. L. Pascu
Affiliation:
National Institute for Laser, Plasma and Radiation Physics, P.O.Box, MG-36, 077125, Bucharest
E-mail
mihai.boni@inflpr.ro
Keywords:
micro-droplets, Raman spectra, dimethyl sulfoxide, DMSO, Nd:YAG laser
Abstract:
The ultra-pure water and the dimethyl sulfoxide (DMSO) are some of the most utilised solvents of medicines in basic and clinical studies. To understand the interaction of the drugs with different targets of theirs it is necessary to understand the behaviour of solvents in the conditions in which the drugs are used. Consequently, in this paper, properties of the Raman spectra of the ultra-pure water and DMSO are reported when the samples are prepared in bulk or as micro-droplets; a comparison of the Raman spectra obtained in the two cases is performed.
The Raman spectra of the micro-droplets are excited at 532nm and 355nm (the second, respectively, third harmonic of a Nd:YAG laser) for both cases: ultra-pure de-ionized water and DMSO. The spectra measured on micro-droplets of DMSO or ultra-pure water appear to be in agreement with data reported in the literature. In order to better understand the droplets behaviour at interaction with laser radiation the temperature of DMSO and water droplets was measured in real time; the temperature changes of the droplets during the exposure were of , at most, 1- 2 °C which shows that the temperature variations did not significantly contribute in altering the measured Raman spectra.
The Raman spectra measurements has shown that the use of micro-droplets allows obtaining the same data for a small volume of substance (12.5 µL) instead of bulk.
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