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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2024-11-22 1:30 |
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Conference: Bucharest University Faculty of Physics 2012 Meeting
Section: Biophysics; Medical Physics
Title:
Reconstruction of brain vasculature from contrast-enhanced magnetic resonance imaging for stereotactic implantation of electrodes
Authors:
A. BARBORICA (1,2), C. DONOS (2), R.C. BOBULESCU (2) J. CIUREA (3), I.MINDRUTA (4,5), B. BALANESCU (3)
Affiliation:
(1) FHC Inc, Bowdoin ME, USA
(2) Physics Department, University of Bucharest, Bucharest, Romania
(3) Bagdasar-Arseni Hospital, Bucharest, Romania
(4) University Emergency Hospital, Bucharest, Romania
(5) Carol Davila University, Bucharest, Romania
E-mail
cristidonos@yahoo.com
Keywords:
Brain vasculature, MRI Electrode Trajectory
Abstract:
Visualization of brain’s blood vessels is a critical step related to patient safety during the placement of electrodes within deep brain structures for Deep Brain Stimulation (DBS) or for stereoelectroencephalography (SEEG). Contrast-enhanced MRIs were filtered using 3D Frangi vesselness filter. Using Matlab (Mathworks, Natick, MA, USA), a 3D model of the blood vessels was obtained by thresholding the Frangi-filtered MRI. Detected vascular network density was adjusted by setting different threshold values. For use in the surgical planning software, the Frangi-filtered volume was exported as a DICOM series and co-registered with other scans (CT, MRI), so that blood vessels can be overlaid with the other brain structures. We have applied this technique to a number of 9 patients undergoing bilateral DBS electrode implantation and to 2 cases of temporal lobe epilepsy requiring pre-surgical SEEG evaluation. By adjusting the planned electrode trajectories to avoid major blood vessels visualized through our method, we have succeeded in improving patient safety.
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