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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2024-11-22 2:18 |
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Conference: Bucharest University Faculty of Physics 2010 Meeting
Section: Applied Nuclear Physics
Title:
Process for Producing Radioactive-Fluorine-Labeled Compound for Positron Emission Tomography
Authors:
Liviu-Stefan Craciun (1), Cristina Ionescu (1), Olimpiu Constantinescu (1), Petru Mihai Racolta (1), Mihai Straticiuc (1), Ion Burducea (1), Emil Stefan Barna (2)
Affiliation:
(1)Horia Hulubei National Institute of Physics and Nuclear Engineering - IFIN HH, Str. Atomistilor no.407, Magurele – 077125, Ilfov, Romania
(2)University of Bucharest, Faculty of Physics
E-mail
cliviu@nipne.ro
Keywords:
PET, FDG, radiosyntheses
Abstract:
Positron emission tomography (PET) is a powerful metabolic imaging technique utilizing one of the best radiopharmaceutical we have ever used [18-F]-fluorodeoxyglucose (FDG). The half-life of 109.7 min allows time-consuming multi-step radiosyntheses as well as extended PET studies of slower biochemical processes. The present work will focus on the design of automated systems for the rapid synthesis of PET radiotracers labeled with 18-F. This equipment was constructed at IFIN-HH for research of short lived radioisotopes for PET investigation. [18-F] fluoride was produced at the U-120 cyclotron by irradiation of H2O enriched 97% in 18O, with deuterons of 13 MeV or protons of 8 MeV. The irradiated H2O was transferred (injected) into the radiochemistry full automated processing systems which ensure the separation of [18-F] - from H2O, the labeling with [18-F] of a precursor compound by an acid or basic hydrolysis; then it is transformed in the radiopharmaceutical with [18-F] and finally purified a selective absorbants. The system is easy to operate and contain a programmable logical controller which manages the entire operation program stored in its internal memory. The synthesis module has configurated so that it is enough flexible to accomplish and other nucleophile reactions of labeling with short lived radioisotopes.
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