| |
 |
UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2024-11-22 2:33 |
 |
|
|
|
Conference: Bucharest University Faculty of Physics 2010 Meeting
Section: Applied Nuclear Physics
Title:
Radionuclidical purity essential parameter in quality control of radiopharmaceuticals
Authors:
Catalina Cimpeanu (1), Catalina Barna (1), Beatris Neacsu (1)
Affiliation:
(1) Horia Hulubei National Institute for Physics and Nuclear Engineering, Magurele, Romania
E-mail
ccimpeanu@yahoo.com
Keywords:
radionuclidical purity; radiopharmaceuticals
Abstract:
Radiopharmaceuticals are radioactive labeled compounds fulfilling the requirements for pharmaceutical products, used in radiodiagnosis or radiotherapy. In order to become a radiopharmaceutical product, a chemical product undergoes a labeling procedure using a certain radionuclide with adequate nuclear characteristics for the desired use in nuclear medicine. The selection of a radionuclide for radiodiagnosis and radiotherapy must take account of some aspects: (a) the radionuclide must have such nuclear characteristics so the gamma radiation energy to allows obtaining of good scintigraphies; (b) the radionuclide must have adequate radiation energies and half-life so the internal irradiation dose delivered to the patient after administration of radiopharmaceutical, for the whole duration of the medical procedure, to be as low as possible; (c) the radionuclide must have such chemical properties that its biological behavior to answer the desired purposes (localization only in the targeted organ) and the time to its clearance form the organism (biologic half-life) to be as short as possible. The product must have a selective affinity toward certain organs or groups of organs and in some specific cases to be metabolized being physiologically inert and non toxic.
Any labeled compound and especially the radioactive organic compounds, such as radiopharmaceutical products, undergo in time a decay process. For this reason, the radionuclidical purity is one essential parameter in the quality control of radiopharmaceuticals.In this work, we present aspects regarding the radionuclidical purity determination for radiopharmaceutical products: Sodium iodide (131I) solution; Sodium iodide (131I) capsules for radiodiagnosis; Sodium pertechnetate (99mTc) injection (non-fission).
|
|
|
|