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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2024-11-22 2:30 |
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Conference: Bucharest University Faculty of Physics 2007 Meeting
Section: Electricity and Biophysics
Title:
Spectral studies of some alkylphenylpyridynium compounds under UV iradiation
Authors:
M. Dicu(1), A. Staicu(2), D. Gazdaru(1), M. L. Pascu(2)
Affiliation:
1. University of Bucharest, Faculty of Physics, P.O.Box MG-11, Bucharest,
Romania.
2. National Institute for Laser, Plasma and Radiation Physics, Laser Department,
P.O.Box MG-36, 077125 Bucharest, Romania.
E-mail
gazdaru@rdslink.ro
Keywords:
alkylphenylpyridynium compounds, UV iradiation, photodynamic therapy
Abstract:
The polycyclic aromatic hydrocarbons (PAH) are potentially carcinogenic molecules, while, in contrast, the substituted PAH derivatives may serve as anticancer agents, and consequently as chemotherapeutics
Phenyl-pyridine compounds present a high interest for Photodynamic Therapy due to their important anti-inflammatory and anti-tumour properties.
In this study, we present a spectroscopic characterization of new synthesized PAHs derivative, (phenyl-pyridine compound), acridine derivative namely: BG 204. The absorption, excitation and emission spectra of the different compound solutions (2 • 10 M in water) were recorded, after their exposure to the ultraviolet and vizible light generated by a Xe lamp with a power density of 530 mW/cm . The absorption spectra exhibited several spectral bands between 200 nm – 550 nm. In the fluorescence excitation measurements, spectral bands were observed in correspondence with the absorption bands. The fluorescence emission have intensity maxima between 300 nm and 700 nm.
One goal on this study was to investigate the influence of concentration on the studied solutions. Using a concentration range , from 10 to 8•10 , the results showed a polimerization phenomenon (the presence of two or more molecular species). Experimental data revealed the presence of polymers beginning with concentration 8•10 M.
It was observed that the compound BG 204 is sensitive to irradiation because the solutions of these compounds exhibited a decrease of the absorption, excitation, and emission band intensities as a function of irradiation time.
FTIR studies on the non-irradiated samples are in progress in order to explain the effect of UV- VIS irradiation upon the structural modifications of BG 204.
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