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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2024-11-23 12:01 |
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Conference: Bucharest University Faculty of Physics 2008 Meeting
Section: Electricity and Biophysics
Title:
Studies of the effects of pyridinium compounds exposed to optical radiation on pseudotumoural tissues
Authors:
Ruxandra Pascu(1*), M. Trifu(2), M. Dumitrescu(3), Abdallah Mahamoud (4), Angela Staicu(5), B. Carstocea(6), M. L. Pascu(5)
Affiliation:
1 University Emergency Hospital Bucharest
2 Central Military Hospital, Experimental Medicine Department, Bucharest
3 Central Military Hospital, Anatomopathology Department, Bucharest
4 Faculty of Pharmacy, Mediterranean University, Marseille, Cedex 5
5 National Institute for Lasers, Plasma, and Radiation Physics, Bucharest
6 Central Military Hospital, Ophthalmology Clinic, Bucharest
E-mail
Keywords:
cytostatics, optical radiation
Abstract:
The paper reports about the effects of alkyl substituted benzo[b]pyridinium compounds which are potential or effective cytostatics, on the pseudotumoural tissues after their exposure to ultraviolet and visible optical beams. The study of the modifications of the absorption, fluorescence and FTIR spectra of the investigated compounds was performed to evidence the molecular modifications after exposure to uncoherent optical radiation. The selection of compounds which were most sensitive to the exposure to optical beams was made and their action on the pseudotumoural tissues was studied. Results obtained for “in vivo” applications of the BG 1120 on pseudotumoural tissues are reported; the BG 1120 is able to diminish faster, based on mechanisms which are proposed in the paper, when irradiated, the inflammations and the neovascularisations in the conjunctival tissue.
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