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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2024-11-23 18:20 |
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Conference: Bucharest University Faculty of Physics 2009 Meeting
Section: Biophysics; Medical Physics
Title:
A unified reduced multicompartment electrophysiology model of cardiomyocytes from different territories
Authors:
B. Amuzescu, I.C. Barbu, N. Pascu, T. Selescu, M.L.Flonta
Affiliation:
Dept. Biophysics& Physiology, Faculty of Biology, University of Bucharest
E-mail
bogdan@biologie.kappa.ro
Keywords:
cardiomyocyte, Hodgkin-Huxley model, Markov model, calcium dynamics
Abstract:
Over a period of about 50 years, mathematical models of cardiomyocyte electrophysiology gained progressively in complexity, accuracy and level of detail. Starting in the early 1960s, when Hodgkin-Huxley based models incorporated the emerging properties of potassium and later of calcium (slow inward) currents, along with the first models of calcium balance built in the 1980s, comprising calcium release and reuptake from the sarcoplasmic reticulum (DiFrancesco and Noble 1985), and calcium buffering in different compartments (Hilgemann and Noble 1987), the recent trends of this evolution consist in employing detailed gating kinetics for various ion channels, relying on Markov chains of independent random events.
Our approaches aim to develop realistic multicompartment kinetic models of cardiomyocytes from various territories (sino-atrial and atrio-ventricular node, atrium, bundle of His, Purkinje fibers, and various ventricular regions – subendocardium, midmyocardium, and subepicardium) as a first step within an attempt to model the electrical activity at the whole organ level. We have translated to C++ and a Java-based environment (CESE – Cell Electrophysiology Simulation Environment) the guinea pig ventricular cardiomyocyte model created by the group of Prof. Yoram Rudy (Faber et al. 2007), and added kinetic models for the fast and slow component of transient outward current (Shannon et al. 2004), and a four-state circular allosteric model of the hyperpolarization-activated current (Männikö et al. 2005). Relying on the similarity, from a mathematical point of view, between the diadic “subspace” of the Faber-Rudy (FR) model, and the submembrane “subspace” of sinoatrial cell models of Kurata et al. (2002, 2008), we have adjusted FR parameters to obtain central and peripheral sino-atrial node models with pace-maker properties. Similarly, starting from the human left ventricular epicardial model of Iyer et al. (2004), and using parameters adapted according to ten Tusscher et al. (2004), we have generated models of human subepicardial, midmyocardial, and subendocardial cardiomyocytes.
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