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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2024-11-21 21:06 |
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Conference: Bucharest University Faculty of Physics 2008 Meeting
Section: Optics, Spectroscopy, Plasma and Lasers
Title:
Determination of the Pharmacokinetics of Methotrexate by Scintigraphic
Monitoring of [99mTc] Pteridinic Derivatives Biodistribution
Authors:
R. Fumarel(1), P. Albert(1), A. Hurduc(1), N. Stafidov(1), M. L. Pascu(2)
Affiliation:
1“Professor Doctor Alexandru Trestioreanu” Institute of Oncology, Bucharest
2 National Institute for Laser, Plasma and Radiation Physics, Bucharest
E-mail
Keywords:
photosensitizer, optical irradiation, malignant tumours
Abstract:
The use of Methotrexate (MTX) as a photosensitizer in conjunction with optical irradiation of the solid malignant tumours requires the knowledge of the cytotoxic agent intratumoural retention time. That can be made by sequential scintigraphic procedures and implies radioactive labeling with the isotope 99mTc. Radioactive Chromatography and ultraviolet-visible absorption spectra measurements confirm the possibility of synthesizing a radiopharmaceutical (2,4 diamino 6-pertechnetate pterine) that pursues the biodistribution of MTX. Sequential scintigraphy at 15 minutes shows that the MTX intratumoural retention time is approximately one hour from the systemical administration in bolus.
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