Faculty of Physics - University of Bucharest

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FACULTY OF PHYSICS

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2024-11-22 2:14

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Conference: Bucharest University Faculty of Physics 2013 Meeting

Section: Optics, Spectroscopy, Plasma and Lasers

Title:

Study of the optical properties of 2-thiohydantoin derivatives

Authors:

A. Smarandache (1), A. Pascu (1), I. Andrei (1), J. Handzlik (2), K. Kiec-Kononowicz (2), A. Staicu (1), M.L. Pascu (1)

Affiliation:

(1) National Institute for Lasers, Plasma and Radiation Physics, Laser Department, P.O.Box, MG-36, 077125, Bucharest, Romania

(2) Department of Technology and Biotechnology of Drugs,Medical College, Jagiellonian University, Cracow, Poland

E-mail

adriana.smarandache@inflpr.ro

Keywords:

hydantoin derivatives, FTIR spectroscopy, Nd:YAG laser, time resolved phosphorescence, singlet oxygen lifetime.

Abstract:

Lately it is a big challenge to identify ways to combat the failure of treatment of infectious diseases and cancer, induced by multidrug resistance. A group of chemicals whose anticancer properties were recently studied is constituted by the hydantoins class. These are heterocyclic organic compounds which were obtained initially through the reduction of allantoin, a constituent of urine. Depending on the nature of substitution on the hydantoin ring, these derivatives possess a wide range of pharmaceutical properties.In this study, the optical properties of generically called SZ-2 are presented. A stability assay using UV/VIS/NIR spectra was performed up to 250 days, as well as FTIR spectroscopic characterization. Time resolved phosphorescence of singlet oxygen (at λ=1270 nm) was measured. Liquid samples of SZ-2 in DMSO were exposed to 355 nm pulsed laser radiation emitted by a Nd:YAG laser for different time intervals. The behavior of irradiated SZ-2 molecules was highlighted based on their absorption spectra before and after coherent light irradiation. All the monitored solutions have not preserved their absorption characteristics, considering the cumulated measuring errors. For solutions kept at 220C in ambient light conditions, it was observed the appearance of new absorption peaks in NIR, whose intensities increasing in time. Also, a 4 nm hypsochromic shift of 1940 nm maximum was noticed. Following laser beam exposure, one may observe that the spectral fingerprint in UV disappeared after 10 min. In the mean time the 246 nm peak is increasing with the duration of laser beam exposure.The singlet oxygen lifetime was determined by recording the phosphorescence decay curves over 1000 averaged Nd:YAG laser shots, emitted at 355 nm. The result is comparable with reference studies, suggesting that SZ-2 could be a serious candidate for Photodynamic Therapy. Acknowledgements: This research was supported by Program LAPLAS 3, PN 09 39/2009 and by CNCS – UEFISCDI projects PN-II-ID 71/2011 and PN-II-PT 85/2012. Authors would like also to acknowledge the COST MP1106 and BM1003 networks.