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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2024-11-22 1:24 |
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Conference: Bucharest University Faculty of Physics 2005 Meeting
Section: Electricity and Biophysics
Title:
The modification of phenyl – pyridine compounds under UV irradiation: FTIR investigation
Authors:
Felicia Ungureanu, Letitia Voicu, Ionut Andrei
Affiliation:
National Institute for Laser, Plasma and Radiation Physics
E-mail
feci_comin@yahoo.com
Keywords:
Phenyl-pyridine compounds, UV irradiation, FTIR
Abstract:
Phenyl-pyridine compounds present a high interest for Photodynamic Therapy due to their important anti-inflammatory and anti-tumor properties. In this study, two phenyl-pyridine compounds were investigated BG204 (3-amino, 9-thio [2-N-N-diethylaminoethyl] acridine) and BG 1120 (4,5 bis [thio(2-N-N-diethylaminoethyl)], 9methyl 1,8-diazantracene), because they present modification during UV irradiation. In order to elucidate these modifications FTIR spectroscopy was used. BG204 and BG1120 were UV irradiated using a Xe lamp, with a power density of 11mW/cm2, for 1 hour, respectively 3 hours. The FTIR spectra, in the range of 4000 cm-1 – 400 cm-1, were performed by a Nicolet Magna IR 550 spectometer. The results of the analyzed samples showed that these molecules are photo-reactive, and their therapeutic effects can be improved by UV irradiation.
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