UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS

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2024-11-23 17:59
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Conference: Bucharest University Faculty of Physics 2014 Meeting


Section: Biophysics; Medical Physics


Title:
3D Conformational interstitial brachytherapy planning for soft tissue sarcoma – early experience in Emergency Central Military Hospital ”Dr. Carol Davila”


Authors:
Alina TĂNASE(1,3), M. DUMITRACHE(2,3)


Affiliation:
1) Emergency Central Military Hospital ”Dr. Carol Davila” Bucharest, Romania

2) Institute of Oncology ”Prof. Dr. Al. Trestioreanu”, Bucharest, Romania

3) University of Bucharest, Faculty of Physics, Bucharest, Romania



E-mail
alinatanasemail@yahoo.com


Keywords:
Soft tissue sarcoma, 3D conformational, interstitial brachytherapy


Abstract:
Soft tissue sarcomas (STS) are malignant tumours that originate in the body soft tissues (including muscle, fat, blood vessels, nerves, tendons). STS are very rare (they account for less than 1 % of all new cancer cases each year) but very serious, especially if diagnosed when the disease is more advanced. High-dose rate brachytherapy (HDR) for STS is often used following surgery, to help eradicate any cancerous cells that remain after the procedure. With HDR brachytherapy, radiation is deposited inside the body, in the area of the tumour, thereby delivering a maximum dose while minimizing exposure to the surrounding healthy tissue. In this work we present our early experience in 3D conformational interstitial brachytherapy planning with BrachyVision v.11 (Varian software) for a forearm STS. The procedure was performed in a team, involving the effort of the surgeon, radiation oncologist, pathologist, medical physicist and radiation therapy technician. The case was a single-plan implant of 4 catheters, placed parallel to the incision (end of march 2014). 3D treatment planning required computed tomography after recovery from surgery procedure. The clinical target volume (CTV) was defined as the volume of tissue with risk of microscopic spread, and includes the preoperative image tumour (visualized by CT - MRI fusion). Source loading was performed 7 days after catheters implant and wound closure (single 192Ir source, GammaMed Plus iX afterloader equipment); 3 Gy were delivered twice daily, 5 days. We follow now the response to BT treatment. At the first medical examination after treatment (end of May 2014), the patient has no problem moving her fingers. The forearm revealed hematoma, but no infection or seroma.