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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2024-11-27 9:44 |
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Conference: Bucharest University Faculty of Physics 2014 Meeting
Section: Optics, Spectroscopy, Plasma and Lasers
Title:
Investigation of irradiation effects on medicine solutions exposed to UV laser beams in droplet and bulk
Authors:
I.R. ANDREI (1), Tatiana ALEXANDRU (1,2), M. BONI (1,2), Andra DINACHE (1), V. NASTASA (1,2), M.L. PASCU (1,2)
Affiliation:
1) National Institute for Laser, Plasma and Radiation Physics, Department of Lasers, str. Atomistilor 409, 077125, Magurele, Romania
2) University of Bucharest, Faculty of Physics, 077125, Bucharest, Romania
E-mail
ionut.andrei@inflpr.ro
Keywords:
laser irradiation, microdroplet, CPZ, photoreaction compounds
Abstract:
The multiple drug resistance (MDR) developed by bacteria requires flexible approach to find medicines able to overcome it. At the moment, the main way to fight MDR is to develop new medicines while this is costly, time consuming and accompanied by side effects that cannot be foreseen at the research/development stage. One alternate solution could be the exposure of existing medicines solutions to UV laser beams in order to obtain photoproducts that are efficient against bacteria. This can be done in bulk (volumes of the order of mL) droplets (volumes of the order of µL). In this paper the interactions of two different UV pulsed laser beams (266 nm and 355 nm) with microdroplets in pendant positions in air, and bulk containing solution of 10mg/mL Chlorpromazine (CPZ) in ultrapure water are investigated. The laser beam may be partially or fully absorbed by the medicine components, in which case the interaction is called resonant or it is not absorbed exerting only mechanical effects in which case the interaction is defined as unresonant. It was observed that the resonant effects are irradiation wavelengthdependent, and produce faster modifications of the absorbing molecules at 355 nm rather than the exposure at 266 nm.
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