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2024-11-22 2:21

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Conference: Bucharest University Faculty of Physics 2015 Meeting

Section: Optics, Spectroscopy, Plasma and Lasers

Title:

Investigations on the interaction of unexplored hydantoin derivatives solutions with optical beams

Authors:

Adriana SMARANDACHE(1,2), Mihai BONI(1,2), Viorel NASTASA(1,2), Ionut R. ANDREI(1), Jadwiga HANDZLIK(3), Katarzyna KIEC-KONONOWICZ(3), Leonard AMARAL(4), Mihail Lucian PASCU(1)

Affiliation:

1) National Institute for Laser Plasma and Radiation Physics, Str. Atomistilor 409, Magurele 077125, Romania, e-mail: adriana.smarandache@inflpr.ro

2) Faculty of Physics, University of Bucharest, Str. Atomistilor 405, Magurele 077125, Romania

3) Medical College, Jagiellonian University, Sw. Anny 12, 31-008 Cracow, Poland

4) New University of Lisbon, Institute of Hygiene and Tropical Medicine, Rua da Junqueira 100, Lisbon, Portugal.

E-mail

adriana.smarandache@inflpr.ro

Keywords:

absorption spectra, contact angle, droplets, hydantoin derivatives, laser induced fluorescence, Nd:YAG laser, surface tension

Abstract:

The management of multidrug resistance in refractory diseases can be successfully achieved using efficient drug delivery systems [Kumar N., 2014]. This study presents the spectral properties of two novel hydantoin derivatives having promising pharmaceutical features [Kiec-Kononowicz K. et al., 2002; Handzlik J. et al., 2012]. SZ2 (C10H7ClN2OS, M=238.69 g/mol) and SZ7 (C17H14N2O2S, M=310.08 g/mol) were prepared as solutions in DMSO at different concentrations. They were kept in various light/temperature conditions up to 5 weeks. Also, solutions of SZ2 and SZ7 at 10-3M in DMSO were exposed both in droplets and bulk samples to optical radiation emitted at 266 nm by a Nd:YAG laser, for different time intervals. There are reviewed the wetting properties of these solutions, too. The stability of the investigated solutions was monitored based on absorption UV/VIS spectra before and after light exposure. This item (e.g. solutions stability) shows particular importance in terms of samples handling for advanced microbiologic analysis. Surface tension and contact angle measurements of solutions were performed using a Drop and Bubble Shape Tensiometer. Likewise, the influence of laser beam exposure of liquid samples was investigated by laser induced fluorescence (LIF) method. Discussion related to the stability of the investigated samples and the evolution of the wetting properties is made. On the other hand, the analysis of the LIF spectra reveals the molecular modifications induced by laser beam exposure on our materials.

References:

Handzlik J. et al., Acta Poloniae Pharmaceutica - Drug Research 69(1): 149-153, 2012.

Kiec-Kononowicz K., Szymanska E., Il Farmaco 57: 909-916, 2002;

Kumar N., Kumar R., Nanotechnology and Nanomaterials in the Treatment of Life-Threatening Diseases, Elsevier Inc., 54-98, 2014.

Acknowledgement:

A. Smarandache and V. Nastasa are supported by the strategic grant POSDRU/159/1.5/S/137750. The authors acknowledge the financial support of the ANCS by projects number PN-II-ID-PCE-2011-3-0922 and PN-II-PT-PCCA-2011-3.1-1350, and the MEN-CDI Nucleu project: PN0939/2009. This work was also supported by COST MP1106.