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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2024-11-22 2:26 |
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Conference: Bucharest University Faculty of Physics 2015 Meeting
Section: Biophysics; Medical Physics
Title:
Stability evaluation of colloidal systems for medical treatments
Authors:
V. NASTASA (1,2), A. SMARANDACHE (1,2), K. SAMARAS (3), T. D. KARAPANTSIOS (3), M. L. PASCU (1,2)
Affiliation:
1National Institute for Laser Plasma and Radiation Physics, Magurele, Romania
2Faculty of Physics, University of Bucharest, Romania
3Aristotle University, Chemistry Department, Thessaloniki, Greece
E-mail
viorel.nastasa@inflpr.ro
Keywords:
colloids, foam stability, nanocarriers
Abstract:
One of the main issues of the XXIst century is represented by the multiple drug resistance (MDR) to treatment, developed by bacteria and malignant tumours; therefore finding ways to overcome MDR is of significant interest. One of the alternatives to the existing medicines and treatment procedures in overcoming MDR is strengthening the effects of medicines by improving their delivery methods. Such a method is represented by the generation, transport and use of micro/nano-droplets which contain drugs. This approach can reduce the medicine consumption by generating micro-droplets which contain drugs incorporated in solvents substances; the micro-/nano-droplets can favour a faster delivery to the targets as well as a higher drug concentration in them.
This work reports the results obtained for different type of colloidal systems and their possible use either as vehicles to transport medicines to specific targets or, locally, to treat dermal and/or venous diseases.
Different mixing methods lead to colloids with different targeted properties specific to their intended use.
In this study, emulsions and foams are generated using several mixing techniques. The results are compared as regards the component droplet/bubble size distribution and their stability in time.
The droplets/bubbles diameters were measured using both light scattering and microscopy methods. It is found that at appreciably high energy input (high rotation speed, large pressure difference), droplets with diameters smaller than 100 nm can be produced [1].
Also, the factors that could influence the stability of the obtained colloids have been studied. The effect of different surfactants on foams and emulsions added at various concentrations is evaluated. It was observed that by adding anionic or nonionic surfactants in small concentrations, the stability of a given foam can be increased with very small variations of the mean bubble size [2].
The interaction of laser radiation with some of the studied colloidal systems is also presented [3].
References:
References
[1] V. Nastasa, K.Samaras, I.R.Andrei, M.L.Pascu, T.Karapantsios Study of the formation of micro and nano-droplets containing immiscible solutions Colloids and Surfaces A: Physicochem. Eng. Aspects 382, 246–250, 2011
[2] V. Nastasa K. Samaras M.L. Pascu T.D. Karapantsios, Moderately stable emulsions produced by a double syringe method, Colloids and Surfaces A: Physicochem. Eng. Aspects, http://dx.doi.org/doi:10.1016/j.colsurfa.2014.01.044, 2014
[3] A. Smarandache, M.A. Trelles, J.Moreno-Moraga, M. L. Pascu, “Applications of Polidocanol in varicose vein treatment assisted by exposure to Nd:YAG laser radiation”, in Nd YAG Laser, Ed. D. C. Dumitras, In Tech, Croatia, ISBN 979-954-307-327-8, 223 – 254, 2012
Acknowledgement:
Acknowledgements
This work was supported by CNCS-UEFISCDI through project number PN-II-PT-PCCA-2011-3.1-1350, the COST Action MP1106 “Smart and green interfaces - from single bubbles and drops to industrial, environmental and biomedical applications (SGI) and the POSDRU/159/1.5/S/ 137750 project
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