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Conference: Bucharest University Faculty of Physics 2015 Meeting

Section: Optics, Spectroscopy, Plasma and Lasers

Title:

STABILITY OF NEW LASER PRODUCED MEDICINES IN VIEW OF THEIR APPLICATION ON BIOMEDICAL FABRICS

Authors:

Adriana SMARANDACHE (1,2), Agota SIMON (1,2), Andra DINACHE (1), Tatiana TOZAR (1,2), Mihai BONI (1,2), Ionut R. ANDREI (1), M. Carmen MORAN (3,4), Francesca CIRISANO (5),Michele FERRARI (5), Mihail Lucian PASCU (1)

Affiliation:

1) National Institute for Laser Plasma and Radiation Physics, Str. Atomistilor 409, Magurele 077125, Romania,

2) Faculty of Physics, University of Bucharest, Str. Atomistilor 405, Magurele 077125, Romania

3) Facultat de Farmŕcia, Departament de Fisiologia, Universitat de Barcelona, Avda. Joan XXIII s/n, 08028-Barcelona-Spain

4) Institut de Nanocičncia i Nanotecnologia-IN2UB, Universitat de Barcelona, Avda. Joan XXIII s/n, 08028-Barcelona-Spain

5) CNR – Istituto per l’ Energetica e le Interfasi, 16149 Genova, Italy

E-mail

adriana.smarandache@inflpr.ro

Keywords:

absorption spectra, contact angle, Nd:YAG laser, phenothiazines, surface tension

Abstract:

Phenothiazine derivatives are non-antibiotics with a plethora of pharmaceutic properties: antimicrobial, fungistatic, fungicidal etc. Their mechanism of action consists on bacteria replication inhibition by reaching DNA and intercalating between its bases [1,2]. We exposed phenothiazines aqueous solutions to a high energy UV laser beam in order to increase antibacterial activity of resulting mixtures. Safety evaluation of new photoproducts for human use is crucial prior to exposure. In this paper we report results concern the stability of phenothiazines solutions to know the time limits within which they may be used for further biomedical applications. Cytotoxicity screening shows that laser irradiated chlorpromazine and promazine are more efficient against some cell cultures. Interaction of laser irradiated phenothiazines with fabrics shows that promethazine and chlorpromazine have improved wetting properties. Correlation of these two groups of properties shows that chlorpromazine appears to be a more recommended compound for applications on tissue using fabrics as medicine transport vectors.

References:

[1] A. M. Armada, T. Alexandru, D. Machado, B. Danko, A. Hunyadi, A. Dinache, V. Nastasa, M. Boni, J.Ramos, M. Viveiros, J. Molnar, M. L. Pascu and L. Amaral, In vivo 27 (2013) 605.

[2] T. Alexandru, A. Armada, B. Danzo, A. Hunyadi, A. Militaru, M. Boni, V. Nastasa, A. Martins, M. Viveiros. M. L. Pascu, J. Molnar and L. Amaral, Biochem. Pharmacol. 2 (2013) 1.

Acknowledgement:

Aknowledgements: A. Smarandache, T. Tozar and V. Nastasa are supported by the strategic grant POSDRU/159/1.5/S/137750. The authors acknowledge the financial support of the ANCS by projects number PN-II-ID-PCE-2011-3-0922 and PN-II-PT-PCCA-2011-3.1-1350, and the MEN-CDI Nucleu project: PN0939/2009. This work was also supported by COST MP1106.