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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2024-11-22 1:45 |
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Conference: Bucharest University Faculty of Physics 2015 Meeting
Section: Solid State Physics and Materials Science
Title:
Chitosan nanoparticles as drug delivery systems for ferulic acid and L-cysteine. Synthesis based on ionic gelation method and SIESTA simulations
Authors:
Daniela ENCIU (1), Cornelia NICHITA (2,3), George Alexandru NEMNES (4)
Affiliation:
1) INCAS − National Institute for Aerospace Research “Elie Carafoli”, 220 Blvd Iuliu Maniu, Bucharest 061126, Romania
2) University of Bucharest, Faculty of Physics, 3Nano-SAE Research Centre PO Box MG-38, Bucharest-Magurele, Romania
3) National Institute for Chemical-Pharmaceutical Research and Development, 112 Vitan Street, 031299, Bucharest, Romania
4) Faculty of Physics, University of Bucharest, Romania
Materials and Devices for Electronics and Optoelectronics Research Center 077125 Magurele-Ilfov, P. O. Box MG-11, Romania
E-mail
enciu.daniela@incas.ro, cornelianichita@yahoo.com, nemnes@solid.fizica.unibuc.ro
Keywords:
nanoparticles, chitosan, ferulic acid, L-cysteine, ionic gelation, SIESTA
Abstract:
A current challenge in the pharmaceutical scientific research is to identify and to obtain drug delivery systems, biocompatible for the organism, biodegradable, safe and nontoxic. Chitosan nanoparticles are seen as potential polymeric nanocarriers for various drugs. Chitosan is a polysaccharide that meets the required criteria. In this paper, ferulic acid-loaded chitosan nanoparticles were obtained by the method of ionic gelation, using the polyanionic solution of tripolyphosphate (TPP). Ferulic acid is a compound widespread in the plant kingdom, with numerous antioxidant properties. Physical properties of the nanoparticles were investigated by dynamic light scattering (DLS) and UV-Vis spectroscopy. The average size of the chitosan nanoparticles is about 300 nm. Several tests were done in order to study the behavior of ferulic acid loaded chitosan nanoparticles in acidic and basic environments that simulate the gastrointestinal tract. Experimental studies were complemented by density functional theory calculations in the framework of SIESTA package. Furthermore, for a comparative analysis, similar simulations were performed for the case of chitosan nanoparticles logged with the semi essential amino acid L-cysteine.
References:
1) S. A. Agnihotri, N. N. Mallikarjuna and T. M. Aminabhavi, "Recent advances on chitosan-based micro- and nanoparticles in drug delivery," Journal of Controlled Release, vol. 100, pp. 5-28, 2004
2) P. Calvo, C. Remunan-Lopez, J. L. Vila-Jato and M. J. Alonso, "Novel Hydrophilic Chitosan-Polyethylene Oxide Nanoparticles as Protein Carriers," Journal of Applied Polymer Science, vol. 63, pp. 125-132, 1997
3) N. Kumar and V. Pruthi, "Potential application of ferulic acid from natural sources," Biotechnology Reports, vol. 4, pp. 86-93, 2014
Acknowledgement:
The support from the 3Nano-SAE Research Centre and the support from the Materials and Devices for Electronics and Optoelectronics Research Center, both in Magurele, Romania, are thankfully acknowledged. This paper was supported by the Romanian National Authority for Scientific Research, Project PN II PCCA No 113/2012 and PN II PCCA No 210/2014.
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