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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2024-11-22 1:42 |
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Conference: Bucharest University Faculty of Physics 2015 Meeting
Section: Biophysics; Medical Physics
Title:
Curcumin loaded biodegradable copolymer coatings obtained by MAPLE technique
Authors:
I. TIRCA (1,2), V. MARASCU (1,3),N. L. DUMITRESCU (1,2), A. BONCIU (1,3), S. BRAJNICOV (1), V. ION (1), M. DINESCU (1), V. DINCA (1)
Affiliation:
1) National Institute for Laser, Plasma and Radiation Physics, RO-077125 Magurele, Bucharest, Romania
2) University of Craiova, Faculty of Mathematics and Natural Sciences, RO-200585, Craiova, Romania
3)University of Bucharest, Faculty of Physics, RO-077125, Magurele, Bucharest, Romania
E-mail
tirca.ionut2009@gmail.com
Keywords:
MAPLE, drug delivery, polymer
Abstract:
The aim of this paper is to obtain thin films of biodegradable Poly(vinyl alcohol)-Poly(ethylene glycol) with embedded active biologic compound (curcumin). Poly(vinyl alcohol)(PVA) is a synthetic polymer, non-toxic, and water soluble, used for its biocompatible and biodegradable characteristics. Matrix Assisted Pulsed Laser Evaporation (MAPLE) technique was chosen to obtain controlled thin films. New characteristics such as tunable wettability, controlled rate of degradation and coating stability can be obtained. The degradation behaviour was studied by ellipsometry(SE). Morphological characteristics of thin films were investigated by Atomic Force Microscopy (AFM) and Scanning Electron Microscopy techniques (SEM). The structural characteristics of the thin films were characterized by Fourier Transform Infrared Spectroscopy (FTIR). The above studies demonstrated that MAPLE technique could be utilized for designing coatings to be used in drug delivery applications.
Acknowledgement:
The research leading to these results has received funding from the Romanian Ministry of National Education, CNCS – UEFISCDI, under the project PN-II-PT-PCCA 239/2014
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