UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS

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2024-11-23 18:17
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Conference: Bucharest University Faculty of Physics 2016 Meeting


Section: Biophysics; Medical Physics


Title:
High Dose Rate Brachitherapy Applied for Gynecological Cancers - Statistical Analysis on Dose Levels of Organ at Risk


Authors:
Maria VLASCEANU (1,2), Alina TANASE (1), Mihai DUMITRACHE (1), Stefanel VLAD (1)


Affiliation:
1) Emergency Central Military Hospital ”Dr. Carol Davila” Bucharest, Romania,

2) University of Bucharest, Faculty of Physics



E-mail
maria.vlasceanu89@gmail.com


Keywords:
HDR brachyterapy, gynecological cancer, dose, organ at risk


Abstract:
Regarding oncological diseases of gynecological cases, the clinical practice usually involves high dose rate (HDR) brachytherapy procedures. During 2015, in the Radiotherapy Department of the Emergency Central Military Hospital „Dr. Carol Davila” a number of 230 patients have been treated by HDR brachytherapy technique (respectively, 200 sessions for uterine cancer and 379 sessions) for vaginal cancer. The age range of patients was between 23 and 85 years, most of them between 45 and 65 years. Regarding uterine cancer, the prescribed dose was 7.5 Gy/session and for vaginal cancer of 7 Gy/session. For each patient, were delivered 2-4 sessions, during a treatment course, depending on the clinical case. For 95 % of patients, the HDR brachytherapy treatment was delivered, complementary to the external beam treatment, when patients already received 45-50.4 Gy at planning target volume with 1.8 – 2 Gy/session. In order to record the orthogonal digital radiographies for treatment planning, we used a digital C-arm - Siremobil Compact L. Eclipse – BrachyVision 11.0 was used for the treatment planning and a Varian GammaMed plus iX unit, with the Ir192 source, was used for treatment delivery. For uterine cancer,the Fletcher-Suit Delclos applicators and for vaginal cancer Stump, universal cylindrical applicators were used. In this study we used statistical analysis methods in order to characterize the distribution of dose values for organ at risk (rectum and bladder) in accordance with the dose constraints.