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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2024-11-23 18:10 |
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Conference: Bucharest University Faculty of Physics 2016 Meeting
Section: Biophysics; Medical Physics
Title:
Studies on in Vivo Toxicity of Glycerol Coated Iron Oxide Nanoparticles
Authors:
Daniela PREDOI (1), Alina Mihaela PRODAN (2,3), Simona Liliana ICONARU (1), Carmen Steluta CIOBANU (1), Cristina Liana POPA (1), Mircea BEURAN (2,3), Claudiu Stefan TURCULET (2,3), Stefania Mariana RAITA (4)
Affiliation:
1) National Institute of Materials Physics, 105 bis Atomistilor Street, Magurele, Romania,
2) Emergency Hospital Floreasca, 8 Calea Floresca, Bucharest, Romania,
3) Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari, Bucharest, Romania
4) Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine, Bucharest, Romania
E-mail
dpredoi@gmail.com
Keywords:
Glycerol, iron oxide, toxicity, in vivo
Abstract:
In this research, the studies on in vivo toxicity of glycerol coated iron oxide nanoparticles (G-IONPs) in solution are presented for the first time. The aim of this studies was to obtain G-IONP solutions by an unexpensive method (co-precipitation)[1-3]. The TEM studies confirmed the nanometric dimension of the synthesized particles, their cubic structure, and spherical morphology. This study has emphasized the effects of different G-IONP solution concentrations on HeLa cell cultures after the time exposures of 24 h, 48 h, and 72 h. The concentrations of the solution in our in vitro experiments play a major role in cell degradation. Also, it seems that the exposure time determines the level of toxicity of the G-IONP solutions. On the other hand, the in vivo studies on rats of G-IONP solutions revealed that the morphology of harvested tissues deteriorated with the increase of the administered dose. The toxicity of the tested G-IONP solutions on animals has been highlighted by the death, within hours from the last injection, of one of the rats from the one experimental group. However, the toxicity of G-IONP solutions should be further investigated with other cells and other methods in order to fully understand the real threat they can pose if used in biomedical applications.
References:
1. S.L. Iconaru, A.M. Prodan, P. Le Coustumer, D. Predoi, Journal of Chemistry, vol. 2013, Article ID 412079, 6 pages, 2013. doi:10.1155/2013/412079.
2. D. Predoi, C. M. Valsangiacom, Thermal studies of magnetic spinel iron oxide in solution, Journal of Optoelectronics and Advanced Materials, 2007, 1797-1799.
3. E. Andronescu, R. Ghita, C. D. Ghitulica, S. L. Iconaru, D. Predoi, R. Trusca, F. Ungureanu, Superparamagnetic Iron Oxide Synthesis In Polysaccharides, Nr.: Ro128484-A2.
Acknowledgement:
These studies were partially supported by National PN II 131/2014 project.
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