UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS

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2024-11-23 17:42
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Conference: Bucharest University Faculty of Physics 2016 Meeting


Section: Optics, Spectroscopy, Plasma and Lasers


Title:
Laser treated chlorpromazine in interaction with target surfaces of biomedical interest: revelation of results obtained within esa’s “spin your thesis!” programme


Authors:
Ágota SIMON(1,2), A. STOICU(1), Tatiana TOZAR(1), Jack J.W.A. van LOON(3,4), A. DOWSON(4), M-L. PASCU(1,2)


Affiliation:
1) Laser Department, National Institute for Laser, Plasma and Radiation Physics (NILPRP), Măgurele, Ilfov, Romania

2) Faculty of Physics, University of Bucharest, Măgurele, Ilfov, Romania

3) DESC (Dutch Experiment Support Center), Department of Oral and Maxillofacial Surgery / Oral Pathology, VU University Medical Center & Academic Centre for Dentistry Amsterdam (ACTA), Amsterdam, the Netherlands

4) European Space Agency (ESA), ESTEC, TEC-MMG, Noordwijk, The Netherlands


E-mail
agota.simon@inflpr.ro


Keywords:
UV laser radiation, laser modified medicines, medicine droplets, target surfaces, wetting processes, hypergravity conditions, “Spin Your Thesis!”.


Abstract:
The present study brings into the spotlight the HyperMed project, conducted under the aegis of the European Space Agency (ESA) within the “Spin Your Thesis!” 2015 programme. Experiments, regarding the real-time interaction of laser modified photosensitive Chlorpromazine (CPZ) medicine solution with particular target surfaces under simulated hypergravity conditions, have been carried out at the Large Diameter Centrifuge (LDC), developed by ESA at ESTEC, Noorwijk, The Netherlands. The aim of the experiments was to investigate the wetting ability of unirradiated and laser irradiated CPZ solutions during centrifugation up to 20 g hypergravity level. The medicine exhibits enhanced antibacterial properties after a particular laser treatment, this representing an unconventional method to fight spreading of drug resistance on Earth as well as onboard spacecraft/space station. Droplets of drugs have been generated, then, due to the exerted high g, their detachment from a vertical capillary took place, thus achieving the formation of sessile droplets on target surfaces. Results have revealed that the implemented medicine, containing the photoproducts obtained by prolonged exposure to laser radiation, indicated better wetting abilities compared to its unexposed control in the case of some of the studied surfaces, hence providing promising perspectives, for instance, about development of new drug delivery tools.


Acknowledgement:
The present research was supported by CNCS-UEFISCDI through the project PN-II-ID-PCE-2011-3-0922, by the Ministry of Education via NUCLEU project PN1647/2016 as well as by the European Space Agency Education Office through the “Spin Your Thesis!” 2015 programme.