UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS

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Conference: Bucharest University Faculty of Physics 2016 Meeting


Section: Biophysics; Medical Physics


Title:
Stereo EEG–Guided Resection in Patients with Medically Refractory Epilepsy


Authors:
Ana GHEORGHIU (CIUREA) (1,2,3) Jean CIUREA (3), Alin RĂȘINA (3), Ioan OPRIS (4), Radu MUTIHAC(1)


Affiliation:
1. University of Bucharest, Faculty of Physics, Magurele, Romania

2. Neurology Department, Neurology and Neurovascular Diseases National Institute, Bucharest, Romania

3. Neurosurgery Department, Bagdasar-Arseni Hospital Bucharest

4. University of Miami, Miami Project to Cure Paralysis, USA.



E-mail
anagheorghiu88@gmail.com


Keywords:
Stereo EEG, medically refractory epilepsy, focal cortical dysplasia


Abstract:
Introduction Epilepsy is a chronic neurological disorder. Most patients suffering from this disorder can be treated successfully with antiepileptic drugs, but it is estimated that on average one third of the patients have medically refractory epilepsy. For this patients the surgical intervention is the best option. Stereo EEG (SEEG) is the golden standard in identifying the seizure onset zone (SOZ) and mapping the eloquent cortex. Method and Patients Twenty patients which suffered from intractable epilepsy underwent this procedure. They were evaluated by a multidisciplinary teamwork constituted by neurologists, neurosurgeons, and physicians. Results After the surgical intervention, the outcome was favorable and seizure control was obtained. Eight patients were free of disabling seizures. Focal cortical dysplasia was a common pathology found in our patients. Conclusion Focal cortical dysplasia is the most common cause of medically refractory epilepsy. Patients with seizures which are not controlled by drugs, can benefit of SEEG method. SEEG-Guided Resection is an opportunity for seizure freedom.


References:

1. Cossu M.,Cardinale F.,Castana L., Citterio A, Francione S., Tassi L. et al.: Stereo electroencephalography in the presurgical evaluation of focal epilepsy: a retrospective analysis of 215 procedures.Neurosurgery 57: 706-718,2005

2. Guenot M, Isnard J, Ryvlin P, Fischer C., Ostrowsky K.M. Mauguiere F. et al.: The Talairach SEEG method. Stereo EEG. Indications,results,complications and therapeutic applications in a series of 100 consecutive cases. Sterotact Funct Neurosurj 77:29-32,2001

3. Mohamad Z. Koubeissi,M. D. Difficult to localize intractable Epilepsy: An "In-Depth" Look. Epilepsy Currents,Vol.13,No.2 (March/April)2013 pp.88-89. American Epilepsy Society



Acknowledgement:
Ana Gheorghiu (Ciurea) was supported by the strategic grant POSDRU/159/1.5/S/133652, “Integrated system to improve the quality of doctoral and postdoctoral research in Romania and promotion of the role of science in society” cofinanced by the European Social Found within the Sectoral Operational Program Human Resources Development 2007–2011.