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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2024-11-23 18:00 |
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Conference: Bucharest University Faculty of Physics 2016 Meeting
Section: Polymer Physics
Title:
The influence of polymer coatings on the physico-chemical and biological properties of iron oxide nanoparticles (IONPs)
Authors:
Simona Liliana ICONARU(1), Ciobanu Steluta CIOBANU(1), Alina Mihaela PRODAN(2,3), Mircea BEURAN(2,3), Claudiu Stefan TURCULET(2,3), Daniela PREDOI(1)
Affiliation:
1)National Institute of Materials Physics, 105 bis Atomistilor Street, Magurele, Romania;
2)Emergency Hospital Floreasca Bucharest, 8 Calea Floresca, 014461 Bucharest, Romania
3)Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari, 050474 Bucharest, Romania
E-mail
simonaiconaru@gmail.com
Keywords:
iron oxide nanoparticles, polymer coating, biological studies
Abstract:
Recently, various types of materials have been investigated to serve as targeted drug delivery systems, among which, several are already on the market or being tested in clinical studies. Due to their particular properties iron oxide nanoparticles (IONPs) [1-3] are used in biomedical applications such as contrast agents in magnetic resonance imaging, hyperthermia, targeted drug delivery, cell labelling, RNA and DNA purification, enzyme and protein immobilization and also can be used for bacteria separation. Moreover, IONPs coated with biocompatible materials are the only materials at nanometric scale which are presently approved by FDA (Food and Drug Administration) for clinical use. The aim of this study was to obtain polymer (dextran, sucrose) coated iron oxide nanoparticles (P-IONPs) and to evaluate the influence of the polymer coating on the physico-chemical and biological properties of IONPs. P-IONPs were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The diffraction peaks of P-IONPs were in agreement with those of the standard data for ϒ-Fe2O3 and no new phase or impurity was found. On the other hand, the SEM and TEM investigations revealed that the morphology and size of the ϒ-Fe2O3 nanoparticles was not significantly influenced by the polymer coating. Moreover, the biological studies suggested the polymer coating positively influenced the efficiency of intracellular uptake by HeLa cells of the IONPs. The results suggested that P-IONPs could be suitable candidates for clinical use as biocompatible targeted drug delivery systems.
References:
[1]. A. Ebrahiminezhad, Y. Ghasemi, S. Rasoul-Amini, J. Barar, S. Davaran, , Bull. Korean Chem. Soc. 2012, 33(12):3957-3962.
[2]. A.M. Prodan, S.L. Iconaru, C.S. Ciobanu, M.C. Chifiriuc, M.S., D. Predoi, J. Nanomater, 2013, doi:10.1155/2013/587021.
[3]. C. Riggio, M.P. Calatayud, C. Hoskins, J. Pinkernelle, B. Sanz , T.E. Torres, M.R. Ibarra, L. Wang, G. Keilhoff, G.F. Goya, V. Raffa, Int J Nanomedicine. 2012;7:3155-66. doi: 10.2147/IJN.S28460.
Acknowledgement:
The studies reported in this abstract have been funded by the National PN II 131/2014 project.
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