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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2024-11-23 17:53 |
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Conference: Bucharest University Faculty of Physics 2016 Meeting
Section: Optics, Spectroscopy, Plasma and Lasers
Title:
In vitro evaluation of antitumoral activities of Curcumin loaded biodegradable copolymer
Authors:
I. TIRICA 1,2, V.MARASCU1,3, S.BRAJNICOV 1,2, V.DINCA 1 , D. PELINESCU 4 , I. SARBU 4 , V. MITRAN 5 , A.CAMPEAN 5 , M.DINESCU 1
Affiliation:
(1) National Institute for Laser, Plasma and Radiation Physics, RO-077125 Magurele, Bucharest, Romania
(2) University of Craiova, Faculty of Sciences, RO-200585, Craiova, Romania
(3) University of Bucharest, Faculty of Physics, RO-077125, Magurele, Bucharest, Romania
4 University of Bucharest, Faculty of Biology, Department of Genetics, RO- 060101, Bucharest, Romania
5 University of Bucharest, Faculty of Biology, Department of Biochemistry
E-mail
tirca.ionut2009@gmail.com
Keywords:
MAPLE,drug delivery,osteosarcoma
Abstract:
In this work, novel biodegradable copolymer-Curcumin coatings were developed and evaluated in vitro as antitumoral systems. The chemico- physical structural stability of delivery system and effective release of Curcumin are crucial for controlling and tuning the drug delivery. To facilitate sustained release of Curcumin, the bioactive element was embedded in the biodegradable Polyvinyl Alcohol-Polyethylene Glycol graft coatings obtained by Matrix Assisted Pulsed Laser Evaporation (MAPLE). The strategy used in this study for manufacturing hybrid coatings with various roughness and porosity was to tailor target characteristics (solvent, composition, concentration of curcumin) and deposition parameters (fluence, number of pulses). The morphological characteristics of thin films were investigated by Atomic Force Microscopy and Scanning Electron Microscopy , while the optical and structural characteristics of the thin films were characterized by Fourier Transform Infrared Spectroscopy (FTIR) and UV-Vis spectroscopy. The degradation behavior was studied by ellipsometry (SE). The study demonstrates that Curcumin exhibits efficacy against the osteosarcoma cell lines MG-63, being able to inhibit proliferation and to promote cell death. Our results provide evidence for the potency of the Curcumin- copolymer based coatings as a future treatment of osteosarcomas.
Acknowledgement:
Acknowledgments: The research leading to these results has received funding from the Romanian Ministry of National Education, CNCS -UEFISCDI, under the projects PN-II-PT-PCCA-2013-4-199, PN-II-RU-TE-2014-4-2434 and PN09-39
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