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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2024-11-23 17:51 |
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Conference: Bucharest University Faculty of Physics 2016 Meeting
Section: Biophysics; Medical Physics
Title:
Co-Occurrence of Epileptogenicity Biomarkers: High-Frequency Oscillations and Delayed Responses Evoked by Intracranial Electrical Stimulation in Stereo-EEG Studies
Authors:
Mirela ENE (1),Cristian DONOS (1), Ioana MINDRUTA (2,3), Mihai Dragos MALIIA ( 2), Alin RASINA (4), Jean CIUREA (4), Andrei BARBORICA (1,5)
Affiliation:
1 Physics Department, University of Bucharest, Bucharest, Romania
2 Neurology Department, University Emergency Hospital, Bucharest, Romania
3 Neurology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
4 Department of Neurosurgery, Bagdasar-Arseni Emergency Hospital, Bucharest, Romania
5 FHC Inc, Bowdoin, Maine, U.S.A.
E-mail
e.sabinna19@gmail.com
Keywords:
Single-pulse electrical stimulation, seizure onset zone, epilepsy biomarkers, HFOs, DRs
Abstract:
Epilepsy is one of the most frequent neurological diseases. High-frequency oscillations (HFOs), between 80 and 500 Hz, may be novel markers of the epileptogenic zone.They are the same as in delayed responses (DRs) which are spikes and sharp waves resembling epileptiform discharges, and they are seen with a latency > 100 ms and < 1s after the stimulus artefact.
Using stereotactically implanted depth electrodes for presurgical evaluation, we performed a comparative analysis of stimulation-evoked HFOs and DRs in EEG recordings for 16 patients with drug-resistant epilepsy. We analyzed the information provided by the biomarkers using the logical "and/or" method, and analyzed the combinations between them. To analyze the relationship between biomarkers and the epileptogenic structures we have created 3D maps of the biomarkers distribution by recording location (inbound maps) and by stimulation location (outbound maps). Our study shows that there is a moderate similarity in the information provided by the stimulation-evoked HFOs and DRs. There is a tradeoff between different metrics for SOZ localization.
Acknowledgement:
The work was supported by Romanian government UEFISCDI research grant PN-II-ID-PCE-2011-3-0240.
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