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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2024-11-23 17:38 |
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Conference: Bucharest University Faculty of Physics 2017 Meeting
Section: Optics, Spectroscopy, Plasma and Lasers
Title:
Foam generation and behaviour of unexposed and laser exposed medicine solutions in view of biomedical applications
Authors:
Ágota SIMON (1,2), Mihai BONI (1,2), Tatiana TOZAR (1), Michele FERRARI (3), Mihail-Lucian PASCU (1,2)
*
Affiliation:
1) Laser Department, National Institute for Laser, Plasma and Radiation Physics, Măgurele, Ilfov, Romania
2) Faculty of Physics, University of Bucharest, Măgurele, Ilfov, Romania
3) Consiglio Nazionale delle Ricerche – Istituto per l’ Energetica e le Interfasi, Genova, Italy
E-mail
agota.simon@inflpr.ro
Keywords:
Nd:YAG laser, non-antibiotics, foam generation, time stability
Abstract:
In view of possible applications, it is very important and useful to have an accurate knowledge of foam generation of drug solutions under different conditions, their characteristics and time stability. Liquid foams are metastable materials, therefore their structure ages. Changes in these structures may be caused by drainage of the liquid content, coalescence and/or coarsening. Studies related to the rheology of foams show an ever-higher quality and a constant increase of the number of publications. Due to their large specific surface and low density, these complex fluids are utilised in a broad range of applications [1,2]. The target of the present study has been the implementation of medicine containing foams in biomedical applications, since pharmaceutical products may be more effective against different infections in form of foams, as demonstrated by the use of aetoxisclerol in varicose veins treatment [3-5]. In order to treat infections caused by bacteria already acquiring resistance to a wide range of antibiotics, laser exposed non-antibiotics presented as foams behaving as antibacterials might be one of the best solutions in the future.
References:
[1] I. Cantat, S. Cohen-Addad, F. Elias, F. Graner, R. Höhler, O. Pitois, F. Rouyer, A. Saint-Jalmes, Foams: Structure and Dyanmics, Oxford University Press, 2013.
[2] S. Cohen-Addad, R. Höhler, Rheology of foams and highly concentrated emulsions, Current Opinion in Colloid & Interface Science 19(6), 536-548, 2014.
[3] M. A. Trelles, J. Moreno-Moraga, A. Samaranche, M. L. Pascu, Applications of Polidocanol in varicose vein treatment assisted by exposure to Nd:YAG laser radiation, in Nd YAG Laser, In Tech, Croatia, ISBN 979-954-307-327-8, 223-254, 2012.
[4] M. A. Trelles, J. Moreno-Moraga, J. M. Alcolea, A. Samaranche, M. L. Pascu, Laser in leg veins, in Synopsis of Aesthetic Dermatology & Cosmetic Surgery , Ed. M. L. Elsaie Nova Science Publishers Inc, NY, USA, 2012.
[5] J. Moreno-Moraga, A. Smarandache, M. L Pascu, J. Royo and M. A Trelles, 1064 nm Nd:YAG long pulse laser after polidocanol microfoam injection dramatically improves the result of leg vein treatment: A randomized controlled trial on 517 legs with a three-year follow-up, Phlebology 29(10), 2014.
Acknowledgement:
The present research was supported by the project PN-III-P2-2.1-PED-2016-0420 and by the Nucleu programme-contract project 1647/2016.
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