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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2024-11-23 18:07 |
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Conference: Bucharest University Faculty of Physics 2017 Meeting
Section: Physics and Technology of Renewable and Alternative Energy Sources
Title:
Design and synthesis of chitosan nanoparticles as a drug delivery system
Authors:
Theodor AXENIE(1), Sanda VOINEA(2,3), Faisal AL-BEHADILI(2), Mustafa ALHUSSAINY (2),
Cornelia NICHITA (3,4)
*
Affiliation:
1)Department of Physics, Columbia University, 538 West 120th Street, 704 Pupin Hall, MC 5255, New York, NY, USA
2)University of Bucharest, Faculty of Physics, MG-11, 405 Atomistilor Street, Bucharest-Magurele, Romania
3)University of Bucharest, Faculty of Physics,3Nanosae Research Center, MG-38, 405 Atomistilor Street, Bucharest-Magurele, Romania
4)National Institute for Chemical – Pharmaceutical Research and Development, 112 Vitan Avenue, 031299, Bucharest, Romania
E-mail
cornelianichita@yahoo.com
Keywords:
chitosan nanoparticles, microwave, drug delivery system
Abstract:
Chitosan has become increasingly used in the biomedical and pharmaceutical field due to its characteristics such as: biocompatibility, bioavailability, biodegradability, safety, cationic charge and antimicrobial activity. These properties make it an optimal carrier system, ideal for: tissue engineering, wound healing, burn treatment, artificial skin, ophthalmology, carrier for drug delivering systems. The reason for obtaining chitosan nanoparticles was improving its bioavailability, as well as increasing its potential to be used as a drug delivery system. The nanoparticles were obtained by microwave-assisted ionic gelation. This method was designed in order to significantly reduce the time needed to produce chitosan nanoparticles and also to improve the particle size compared to classical methods. Different concentrations of chitosan have been used and the samples produced have been analyzed through UV-vis spectroscopy to identify the nanoparticles fingerprint and dynamic light scattering (DLS) to determine the particle size of the chitosan nanoparticles.
Acknowledgement:
This work was supported by the Romanian National Authority for Scientific Research, Project PN II PCCA No 210/2014.
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