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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2024-11-23 18:07 |
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Conference: Bucharest University Faculty of Physics 2017 Meeting
Section: Atomic and Molecular Physics. Astrophysics. Applications
Title:
Small-angle neutron scattering on collagen aqueous solutions
Authors:
Chivuța-Ramona BĂDIȚA (1,2), Dorina ARANGHEL(1, 3), A. RADULESCU(4)
*
Affiliation:
1) National Institute for Nuclear Physics and Engineering, Reactorului 30, RO-077125, POB-MG6 Bucharest-Magurele, Romania
2) University of Bucharest, Faculty of Physics, Atomiştilor 405, CP MG - 11, RO – 077125, Bucharest-Magurele, Romania
3) Extreme Light Intrastructure Nuclear Physics (ELI-NP), Reactorului 30, RO-077125, POB-MG6, Bucharest-Magurele, Romania
4) Forschungszentrum Jülich GmbH, Jülich Centre for Neutron Science, 85747 Garching, Germany
E-mail
ramona@tandem.nipne.ro
Keywords:
type I collagen, small angle neutron scattering (SANS)
Abstract:
Collagen is the main structural protein of the extracellular matrix (ECM) and it is found in bone, tendon, cartilage, blood vessels and teeth. Due to its excellent properties it can be processed in different biomaterials used in medicine as wound dressings, collagen shields in ophthalmology, etc. Collagen, along with other components of the ECM helps retain water within the ECM, which is critical to maintain its unique mechanical properties [1]. From over 29 types of collagen that have been identified, over 90% of the collagen in the body is type I [2]. Biomaterials based on type I fibrillar collagen have an important role in medicine. To understand the relationship between the conformation and structure parameters of the collagen molecule in aqueous solution, the morphology and structural features of type I collagen from bovine Achilles tendon was investigated using Small-Angle Neutron Scattering (SANS). We observed from the experimental SANS data that the collagen presents two structural levels whose values are in agreement with ref. [3].
References:
[1]. Alice J. Sophia Fox et al., Sports Health. 1(6), 461–468, 2009.]
[2]. Yury A. Rovensky M.D., Ph.D., D.Sci, 7-12, 2011].
[3]. Bueno EM, Ruberti JW, J Memb Sci., 321(2):250-263., 2008
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