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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2024-11-23 18:26 |
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Conference: Bucharest University Faculty of Physics 2017 Meeting
Section: Biophysics; Medical Physics
Title:
In vitro cytotoxicity assessment of metallic nanoparticles for biomedical applications
Authors:
Roxana Cristina POPESCU(1,2), Adina BOLDEIU(3), Monica SIMION(3), Paul NADEJDE(4), Eugen VASILE(2),Diana SAVU(1), Adriana Maria ACASANDREI(1)
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Affiliation:
(1) Horia Hulubei National Institute for Physics and Nuclear Engineering, Magurele, Romania;
(2) Politehnica University of Bucharest, Bucharest, Romania;
(3) National Institute for Research and Development in Microtechnologies, Bucharest, Romania;
(4) Aghoras Invent SRL, Bucharest, Romania;
E-mail
dsavu@nipne.ro,maionescu_99@yahoo.com
Keywords:
Metallic nanoparticles, in vitro, cytotoxicity, biomedical
Abstract:
In the context of emerging discoveries in the nanotechnology field, many solutions have been found to solve the problems arising in the medical field. Metallic nanoparticles have drawn interest because of their various properties and the possibility to modulate them, in order to fit the final application. Even if today there is a diversity of methods to be employed in the synthesis of such materials and many functionalizing approaches have been implemented, the scientific community is still searching for improvement, in order to reduce the possible cytotoxic effects. Here, we evaluated the in vitro effects of different metallic nanoparticles, synthesized for medical applications, in order to establish their potential outcome against fibroblast cells, at various concentrations. For this, we assessed the viability of the cells after the exposure to nanoparticles, the impact on the cytoskeleton integrity and morphology of the nucleus, but also the potential genotoxic effects.
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