UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS

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Conference: Bucharest University Faculty of Physics 2018 Meeting


Section: Polymer Physics


Title:
Functional polymeric coatings obtained by Matrix-assisted pulsed laser evaporation


Authors:
Simona BRAJNICOV (1,2), Patricia NEACSU (3), Valentina DINCA (1), Valentina MARASCU (1,4), Anca BONCIU (1,4), Anisoara CIMPEAN (3), Maria DINESCU (1)


Affiliation:
1) National Institute for Lasers, Plasma and Radiation Physics, Magurele, Bucharest, Romania

2) University of Craiova, Faculty of Mathematics and Natural Sciences, Craiova, Romania

3) University of Bucharest, Faculty of Biology, Bucharest, Romania

4) University of Bucharest, Faculty of Physics, Magurele, Romania


E-mail
valentina.dinca@inflpr.ro


Keywords:
osseointegration, biointerfaces, MAPLE, osteoblast, cytocompatibility


Abstract:
For most of the applications closely related to the medical field, particularly in the development of orthopedic implants capable of a high degree of osseointegration, one of the top challenges emerges from the need the create complex coatings with tailored properties that facilitate their integration into the organism/bone. The ability to create functional biointerfaces in the form of thin films with controlled morphological and chemical characteristics plays a major factor in achieving these goals. Matrix-assisted pulsed laser evaporation (MAPLE) has been shown to be one of the most versatile techniques when it comes to the creation of these complex coatings, a technique that allows the deposition of organic materials, including natural and synthetic polymers. In our study, the MAPLE technique was successfully used for the deposition of a functional coating based on a recently synthetized copolymer (i.e. Poly(lactide-co-caprolactone)-block-poly(ethyleneglycol)-block-poly(lactide-co-caprolactone) (PLCL-PEG-PLCL)). The structure and morphology of the deposited layers were investigated by Fourier Transform Infrared Spectroscopy (FTIR), Atomic Force Microscopy (AFM) and Scanning Electron Microscopy (SEM). The results from FTIR studies show that, for a well -defined range of process parameters (incident laser fluency, numbers of pulses and spot size) the deposition process does not alter the main functional groups of the deposited material. Moreover, the in vitro preliminary study of osteoblast response to these coatings showed a high degree of cytocompatibility for most of the tested parameters for the MAPLE coatings.


Acknowledgement:
This work was supported by Romanian National Authority for Scientific Research (CNCS–UEFISCDI), under the projects PNII- PT-PCCA-2013-4-199, PN-II-RU-TE-2014-4-2434 and Nucleus program- contract 4N/2016.