Faculty of Physics - University of Bucharest

UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS

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2024-11-22 1:41

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Conference: Bucharest University Faculty of Physics 2018 Meeting

Section: Solid State Physics and Materials Science

Title:

Bioactive thin films based on natural-derived calcium phosphates

Authors:

Anca NICĂREL1, Carmen RISTOSCU2, Gianina POPESCU-PELIN2, Carmen CHIFIRIUC3, George STAN4, Gabriel PRODAN5, Victor CIUPINĂ5, Ion N. MIHĂILESCU2

^*
Affiliation:

1)Faculty of Physics, University of Bucharest, Magurele, Ilfov, Romania,

2)National Institute for Lasers, Plasma and Radiation Physics, Magurele, Ilfov, Romania

3)Department of Microbiology, Faculty of Biology, Romania

4)National Institute of Materials Physics, Magurele-Ilfov, Romania

5)Department of Physics, Ovidius University, Constanta, Romania

E-mail

anca_nicarel@yahoo.com

Keywords:

natural-derived calcium phosphates, hydroxyapatite, biomaterials, bioactive thin films, Pulsed Laser Deposition

Abstract:

Biomaterials synthesized from renewable sources and applied in the form of thin coatings are presently widely used in nano-biomedical field, in particular for drug delivery, new biosensors and coatings with improved functionality for implants. According to current information, in 2020 one individual in two will need a prosthesis. Moreover, drug delivery is vital for the efficient and nontoxic administration. Also, biosensors will answer everyday basic needs for selecting the quality of food, liquids and even air. Pulsed Laser Deposition technique was used in order to synthesize hydroxyapatite coatings from renewable sources (bovine bones, fish bones and composites with zeolites). The experiments were conducted in a vacuum chamber with an KrF* excimer laser source (λ=248nm, τFWHM=25ns). The coatings were grown on titanium discs or silicon wafers, under the same deposition parameters. To improve morphology and crystallinity, coatings were hydrothermally treated at 500°C in a flux of water vapors. Scanning Electron Microscopy was applied to investigate surface morphology of synthesized coatings. The structural properties (degree of crystallinity) of the coatings were assessed by Transmission Electron Microscopy and X-Ray diffraction. Samples were biologically tested in-vitro by MTS and Immunostaining assays in order to evaluate their biocompatibility.