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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2024-11-22 2:33 |
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Conference: Bucharest University Faculty of Physics 2018 Meeting
Section: Physics and Technology of Renewable and Alternative Energy Sources
Title:
Protective effect of chitosan nano-encapsulation against structural changes caused by microwave irradiation
Authors:
Theodor AXENIE (1), Sanda VOINEA (2), Faisal AL-BEHADILI (2), Mustafa AL-HUSSAINY (2), Cornelia NICHITA (3,4)
*
Affiliation:
1)Department of Physics, Columbia University, Phone: + 1(212) 854-3379, 538 West 120th Street, 704 Pupin Hall, MC 5255, New York, NY, USA
2)University of Bucharest, Faculty of Physics, Atomistilor Street 405, Bucharest-Magurele, Romania
3)National Institute for Chemical – Pharmaceutical Research and Development, 112 Vitan Avenue, 031299, Bucharest, Romania, Phone: +4021.321.62.60, Fax: + 4021.322.29.17
4) University of Bucharest, Faculty of Physics, 3Nano-SAE research center, MG-38, Phone: + 4021.457.48.38, 405 Atomistilor Street, Bucharest-Magurele, Romania
E-mail
cornelia@3nanosae.org
Keywords:
chitosan nanoparticles, microwave, nano-encapsulation
Abstract:
Extensively studied in recent year as a drug delivery system, chitosan has attracted significant attention in the fields of biomedical and pharmaceutical research because of its bioavailability, biocompatibility, microbial activity and biodegradability. Because of the long time required to produce chitosan nanoparticles through classical methods of ionic gelation, faster methods of microwave-assisted synthesis have been proposed. In order to assess the availability of such a synthesis method for chitosan nanoparticles meant to be used as drug delivery systems, the ability of chitosan nano-encapsulation to protect the encapsulated drug from any structural change caused by exposure to microwave radiation had to be evaluated. The protective effect of chitosan was highlighted qualitatively through the comparison of several UV-Vis spectra, which showed that the compound present inside the nanocapsules had the same spectral fingerprint as the non-irradiated compound. Moreover, a quantitative analysis was performed: by calculating the entrapment efficiency and by correlating it with the loading capacity to determine the percentage of the drug that was effectively protected by this nano-encapsulation method.
Acknowledgement:
This work was supported by the Romanian National Authority for Scientific Research, Project PN II PCCA No 210/2014.
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