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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2024-11-22 1:41 |
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Conference: Bucharest University Faculty of Physics 2018 Meeting
Section: Physics and Technology of Renewable and Alternative Energy Sources
Title:
Factorial design of ionic gelation process for obtaining monodisperse chitosan nanoparticles
Authors:
Theodor AXENIE(1), Sanda VOINEA(2), Faisal AL-BEHADILI(2), Cornelia NICHITA (3,4)
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Affiliation:
1)Department of Physics, Columbia University, Phone: + 1(212) 854-3379, 538 West 120th Street, 704 Pupin Hall, MC 5255, New York, NY, USA
2)University of Bucharest, Faculty of Physics, Atomistilor Street 405, Bucharest-Magurele, Romania
3)National Institute for Chemical – Pharmaceutical Research and Development, 112 Vitan Avenue, 031299, Bucharest, Romania, Phone: +4021.321.62.60, Fax: + 4021.322.29.17
4) University of Bucharest, Faculty of Physics, 3Nano-SAE research center, MG-38, Phone: + 4021.457.48.38, 405 Atomistilor Street, Bucharest-Magurele, Romania
E-mail
cornelia@3nanosae.org
Keywords:
chitosan nanoparticles, microwave, monodisperse
Abstract:
Chitosan has been studied extensively over the past few years in the biomedical and pharmaceutical field as a nanocarrier, because of its biocompatibility, mucho-adhesiveness, biodegradability and cationic charge. These properties, alongside its antimicrobial activity, make it ideal for drug delivery systems, tissue engineering, wound healing and many other uses. Although the relatively simple preparation method of chitosan is considered an advantage, it takes a long time to complete. Thus, it was necessary to develop a rapid method of synthesis for monodisperse chitosan nanoparticles with improved particle size and stability through a novel microwave-assisted ionic gelation procedure. The samples were produced by controlling for several key parameters, and then evaluated in order to select the most advantageous combination of factors. For this purpose, the samples were analyzed through UV-Vis spectroscopy to identify the spectral fingerprint of the nanoparticles. The size and stability of the chitosan nanoparticles as well as the evolution of these properties in time were assessed through dynamic light scattering (DLS). The morphological properties of the obtained nanoparticles were evaluated using electronic microscopy.
Acknowledgement:
This work was supported by the Romanian National Authority for Scientific Research, Project PN II PCCA No 210/2014.
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