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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2024-11-23 18:09 |
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Conference: Bucharest University Faculty of Physics 2019 Meeting
Section: Polymer Physics
Title:
Biodegradable biointerfaces based on polymeric coatings for in vitro cells analysis
Authors:
Valentina MARASCU (1), Laurentiu RUSEN (1), Anca BONCIU (1,2), Luminita-Nicoleta DUMITRESCU (1,3), Maria DINESCU (1), Valentina DINCA (1)
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Affiliation:
1) National Institute for Lasers, Plasma and radiation Physics, 077125, Bucharest-Magurele, Romania
2)Faculty of Physics, University of Bucharest, 077125, Bucharest-Magurele, Romania
3) Faculty of Mathematics and Natural Sciences,University of Craiova, Craiova, Romania
E-mail
valentina.dinca@inflpr.ro
Keywords:
polymeric coatings, biodegradable biointerfaces, MAPLE method
Abstract:
In the last decades, research on various biomedical topics focused on multifunctional coatings containing biodegradable and biocompatible materials, targeting cells activity and enhancing the bio-response . Enhancing cellular response can be performed by embedding various active factors, such as nanoparticles, proteins. Within this context, this work is focused on embedding 2 active factors(HA and lactoferrin (LF)) within synthetic biodegradable Poly(ethylene glycol)-block-poly(ε-caprolactone) methylether (PEG-block-PCL Me) for the preparation of new biodegradable composite layers by matrix assisted pulsed laser evaporation (MAPLE) method. The resulting features were studied by AFM and SEM. FTIR data demonstrates that the functional groups in the MAPLE-deposited films remain intact for the individual compounds and that LF was not affected by the solvents used for copolymer. The bio-functionality of the coatings has as a final aim the modulated response of osteoblast cells (i.e. adhesion, mineralization).
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