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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2024-11-22 2:05 |
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Conference: Bucharest University Faculty of Physics 2021 Meeting
Section: Polymer Physics
Title:
Hierarchical bioinstructive interfaces obtained by laser processing for biological studies
Authors:
Valentina DINCA(1), Valentina MARASCU(1,3), Anca BONCIU(1,2), Laurentiu RUSEN(1)
*
Affiliation:
1) National Institute for Laser, Plasma and Radiation Physics, 409 Atomistilor, 077125, Magurele, Romania; *FOTOPLASMAT Center;
2) Faculty of Physics, University of Bucharest, RO-077125, Magurele, Romania;
3) Université Paris-Saclay, CEA, INRAE, DMTS, SCBM, F-91191 Gif-sur-Yvette, France.
E-mail
valentina.dinca@inflpr.ro (V.D.)
Keywords:
bioinstructive interfaces; laser; biological studies
Abstract:
This work presents the the nano and micro hierarchical biointerfaces influence on the osteogenic fate of MSCs. The complex interfaces were created via a laser texturing technique. Scanning Electron Microscopy, EDAX, contact angle and surface energy of the analyzed coatings were correlated to biological response on both short and longer term (72h, respectively 28 days). Human MSC were cultured on the developed coatings and viability, proliferation and morphology were evaluated. All surfaces were shown not to exhibit toxicity, as confirmed by LIVE/DEAD assay. Micro and nanotextured ceramic interfaces exhibited an increase in osteogenic differentiation of hMSC cells, results supported by ALP and mineralization assays.
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