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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2024-11-22 1:39 |
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Conference: Bucharest University Faculty of Physics 2021 Meeting
Section: Polymer Physics
Title:
Zinc doped hydroxyapatite powders enriched with zinc oxide for biomedical application
Authors:
Mircea BEURAN (1,2), Alina PRODAN (1,2), Simona Liliana ICONARU (3), Carmen Steluta CIOBANU (3), Anton FICAI (4,5,6), Bogdan Stefan VASILE (4,7), Ionela Andreea NEACSU (4,7), Ecaterina ANDRONESCU (4), Roxana TRUSCA (4), Carmen CHIFIRIUC (6,8,9), Daniela PREDOI (3)
Affiliation:
1) Department of Surgery, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari, Sector 5, 050474 Bucharest, Romania
2) Emergency Hospital Floreasca Bucharest, 8 Calea Floresca, 014461 Bucharest, Romania
3) Multifunctional Materials and Structures Laboratory, National Institute of Materials Physics, Atomistilor Street, No. 405A, P.O. Box MG 07, 077125 Magurele, Romania;
4) Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Material Science, University Politehnica of Bucharest, Bucharest, Romania
5) National Centre for Micro- and Nanomaterials, University POLITEHNICA of Bucharest, 060042 Bucharest, Romania
6) Academy of Romanian Scientists, 060042 Bucharest, Romania
7) National Research Center for Micro and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 060042 Bucharest, Romania
8) Life, Environmental and Earth Sciences Division, Research Institute of the University of Bucharest (ICUB),University of Bucharest, 060023 Bucharest, Romania
9) Microbiology Department, Faculty of Biology, University of Bucharest, 1–3 Portocalelor Lane,
77206 Bucharest, Romania
*corresponding author: dpredoi@gmail.com
E-mail
dpredoi@gmail.com
Keywords:
biological properties, hydroxyapatite nanocomposites, bone regeneration
Abstract:
It is well known that osteoporosis is a major public health problem mainly due to its frequency, morbidity and costs [1]. Fractures that occur after the onset of osteoporosis increase morbidity and have a major impact on quality of life [2]. Therefore, researchers are trying to find safe and effective therapeutic solutions to prevent and treat this silent disease. Due to its excellent physico-chemical and biological properties, hydroxyapatite is used in various biomedical applications (implantology, dentistry, filling material for bone defects, etc.) [3]. Therefore, the doping of hydroxyapatite with zinc ions could be a therapeutic solution that could be used in the management of osteoporosis. The purpose of this study was to obtain and characterize from a physico-chemical point of view the zinc-doped hydroxyapatite (HApZn) powders enriched with zinc oxide. Thus the HApZn/ZnO powders obtained by an adapted precipitation method were analyzed by: X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Raman spectroscopy and by in vivo experiments. Following XRD studies performed on HApZn samples were identify two main mineralogical compounds, namely hydroxyapatite and zinc oxide. According to ASTM sheets, the identified hydroxyapatite is part of the crystalline system hexagonal and zinc oxide in the crystalline system Hexagonal. Also, the nanometric dimensions of the nanoparticles have been noticed. SEM and TEM studies have highlighted the spherical morphology of HApZn / ZnO nanoparticles as well as their tendency to agglomerate. At the same time, Raman studies have shown the presence of vibrational bands specific to the HAp structure. Histopathological visualization revealed that the treatment with the analysed powders had a significant contribution to bone regeneration in ovariectomized mice. Thus, the analysed materials have superior physicochemical and biological properties and could be considered for use in the treatment of osteoporosis.
References:
1. Burge R, Dawson-Hughes B, Solomon DH, Wong JB, King A, et al. Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025. J Bone Miner Res. 2007;22:465-475
2. Pepa GD, Brandi ML. Microelements for bone boost: the last but not the least. Clin Cases Miner Bone Metab. 2016;13(3):181-185. doi:10.11138/ccmbm/2016.13.3.181
3. Noor Z. Nanohydroxyapatite application to osteoporosis management. J Osteoporos. 2013;2013:679025. doi: 10.1155/2013/679025.
Acknowledgement:
This research was funded by the Romanian Ministry of Research and Innovation through the project PN-III-P1-1.2-PCCDI-2017-0629/contract no. 43PCCDI/2018.
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