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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2024-11-22 1:53 |
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Conference: Bucharest University Faculty of Physics 2021 Meeting
Section: Polymer Physics
Title:
New antitumoral biocomposites with controlled release
Authors:
Simona Liliana ICONARU (1), Alina PRODAN (2,3), Mircea BEURAN (2,3), Mariana Carmen CHIFIRIUC (4,5,6), Carmen Steluta CIOBANU (1), Anton FICAI (6,7,8), Bogdan Stefan VASILE (7,9), Ionela Andreea NEACSU (7,9), Ecaterina ANDRONESCU (7), Roxana TRUSCA (7) , Daniela PREDOI (1)
Affiliation:
1) Multifunctional Materials and Structures Laboratory, National Institute of Materials Physics, Atomistilor Street, No. 405A, P.O. Box MG 07, 077125 Magurele, Romania;
2) Department of Surgery, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari, Sector 5, 050474 Bucharest, Romania
3) Emergency Hospital Floreasca Bucharest, 8 Calea Floresca, 014461 Bucharest, Romania
4) Life, Environmental and Earth Sciences Division, Research Institute of the University of Bucharest (ICUB),University of Bucharest, 060023 Bucharest, Romania
5) Microbiology Department, Faculty of Biology, University of Bucharest, 1–3 Portocalelor Lane,
77206 Bucharest, Romania
6) Academy of Romanian Scientists, Ilfov Street, No. 3, 50044 Bucharest, Romania
7) Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Material Science, University Politehnica of Bucharest, Bucharest, Romania
8) National Centre for Micro- and Nanomaterials, University POLITEHNICA of Bucharest, 060042 Bucharest, Romania
9) National Research Center for Micro and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 060042 Bucharest, Romania
*corresponding author: dpredoi@gmail.com
E-mail
dpredoi@gmail.com
Keywords:
antitumoral biocomposites , magnetic nanoparticles, 5-Fluorouracil
Abstract:
The presence of magnetic nanoparticles in bone scaffolds can stimulate the proliferation and differentiation of osteoblasts, the expression of growth factors, and accelerate bone regeneration by improving osteoinductivity. The uniform characteristics of hydroxyapatite (HAp) and Fe3O4 nanoparticles will ensure a rapid response in contact with the magnetic field, which is of interest for their application [1]. 5-Fluorouracil (5-FU) is one of the most widely used chemotherapeutic compounds for the treatment of a wide variety of tumors. HAp-Fe3O4 / 5-FU antitumor systems were obtained by an adapted coprecipitation synthesis method. X-ray diffractograms highlight the presence of hydroxyapatite (ICDD 04-007-5086), magnetite (ICDD 04-011-5952) and 5-Fluorouracil antitumor agent (ICDD 00-039-1860) in the samples obtained. The SEM results highlight the presence of particles with nanometric dimensions and different morphologies. Thus, nanoparticles with a rod-like morphology characteristic of hydroxyapatite can be observed and on the other hand nanoparticles with a polygonal morphology specific to magnetite are also present. Following the SEM studies, the average size of the hydroxyapatite particles was estimated, obtaining a value equal to 90.48 ± 2.03 nm, respectively for the magnetite particles, this being equal to 162.55 ± 4.78 nm. Following the release studies of the antitumoral agent, it was noticed that processes of release and reabsorption of the antitumoral agent take place simultaneously. Cell viability studies performed with a primary osteoblast cell line have shown that cell viability is weakly influenced by the presence of antitumoral systems. Qualitative antimicrobial tests revealed that all investigated samples showed moderate antimicrobial activity against all bacterial strains (Gram-positive bacteria (Staphylococcus aureus ATCC 25923), Gram-negative bacteria (Escherichia coli ATCC 25922) and fungi (C. albicans ATCC 10231)) tested in vitro. The results obtained in this study showed that the HAp-Fe3O4 / 5-FU samples could be a new and effective platform for the treatment of bone metastases.
References:
1. Akhlaghinia, B., et al., The magnetic nanostructured natural hydroxyapatite (HAP/Fe 3 O 4 NPs): an efficient, green and recyclable nanocatalyst for the synthesis of biscoumarin derivatives under solvent-free conditions. Research on Chemical Intermediates, 2019. 45(5): p. 3215-3235.
Acknowledgement:
This research was funded by the Romanian Ministry of Research and Innovation through the project PN-III-P1-1.2-PCCDI-2017-0629/contract no. 43PCCDI/2018.
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