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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2024-11-24 11:39 |
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Conference: Bucharest University Faculty of Physics 2021 Meeting
Section: Biophysics; Medical Physics
Title:
Treatment of ears, nose and throat (ENT) malignant lesions by Intensity-Modulated Radiation Therapy (IMRT)
Authors:
Andreea IONESCU (1), Mihai DUMITRACHE (2)
Affiliation:
1) Department of Electricity, Solid-State Physics and Biophysics, Faculty of Physics, University of Bucharest, Romania
2) Central Military Emergency University Hospital “Dr. Carol Davila”, Bucharest, Romania
E-mail
andreea.ionescu998@yahoo.com
Keywords:
Radiotherapy, IMRT, cancer treatment
Abstract:
Our work assesses the strategy of designing treatment plans for ENT (ears, nose and throat) malignant lesions by an advanced computerized method, namely IMRT (Intensity-Modulated Radiation Therapy). Specifically, we show that it is possible to deliver higher doses of radiation to a tumor while affecting less the surrounding healthy tissues in comparison with other treatment techniques (e.g., 3DCRT).
A number of 15 treatment plans were devised and evaluated in terms of computerized dosimetry parameters such as dose-volume histograms, homogeneity, and conformity indexes. To examine the quality and extent to which the treatment plans agree with the general rules regarding the radiation exposure of surrounding organs to radiological risk, we compared the results against the QUANTEC (Quantitative Analysis of Normal Tissue Effects in the Clinic) recommendations concerning the level of exposure of the healthy organs. In most cases, all prescribed doses were delivered appropriately while protecting the adjacent organs as much as possible. However, in a few cases, the values obtained for the parotid glands exceeded the benchmarks due to the fact that these organs were partially included in the planning target volume. In such circumstances, according to the ALARA principle (as low as possible achievable), the dose constraints were applied to reduce the exposure without adversely affecting the dose distribution.
Acknowledgement:
I would like to thank my coordinator, Prof. PhD. Petrică CRISTEA, for the advice and encouragement provided while elaborating this work.
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