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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2024-11-24 11:15 |
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Conference: Bucharest University Faculty of Physics 2021 Meeting
Section: Biophysics; Medical Physics
Title:
Bio-NanoPlatinum generated from nettle leaves and grape
berries: potential applications in osteosarcoma therapy
Authors:
Marcela-Elisabeta BĂRBÎNȚĂ-PĂTRAȘCU (1), Mihaela BACALUM (2),
Vlad-Andrei ANTOHE (1,3), Sorina IFTIMIE (1), Stefan ANTOHE (1,4)
Affiliation:
(1) University of Bucharest, Faculty of Physics, Department of Electricity, Solid-State Physics and Biophysics,Atomistilor Street 405, 077125 Măgurele, Ilfov, Romania;
(2) Horia Hulubei National Institute for Physics and Nuclear Engineering, Department of Life and Environmental Physics, Reactorului 30, 077125 Măgurele, Ilfov Romania;
(3) Université catholique de Louvain (UCLouvain), Institute of Condensed Matter and Nanosciences (IMCN), Place Croix du Sud 1, B-1348 Louvain-la-Neuve;
(4) Academy of Romanian Scientists, Ilfov Street 3, 050045 Bucharest, Romania
E-mail
santohe@solid.fizica.unibuc.ro
Keywords:
“green” platinum nanoparticles; osteosarcoma; antiproliferative activity
Abstract:
Cancer remains the leading cause of millions of deaths annually, worldwide. Every year many people are diagnosed with osteosarcoma, the most common type of cancer starting in the bones. Recent advances in Green Nanotechnology are trying to fight against this disease. Thus, a special interest has been given to noble metal nanoparticles.
In this study, bio-platinum nanoparticles (bio-PtNPs) were generated through a “green” bottom-up approach, from an aqueous extract of a mixture of nettle leaves and grape berries. The obtained bio-PtNPs were characterized by UV-Vis absorption spectroscopy, as well as by Scanning Electron Microscopy (SEM) and Atomic Force Microscopy (AFM). These bio-PtNPs presented antiproliferative activity against MG-63 osteosarcoma cells. The morphology of MG-63 cells treated with various doses of bio-PtNPs was studied by epifluorescence microscopy.
These findings could be exploited in the development of novel biohybrid systems to be used in osteosarcoma therapy.
Acknowledgement:
Acknowledgments: This work was supported by the Project JINR–RO 2021 No. 38/2021 (IUCN Order 365/11.05.2021), by Romanian Ministry of Research, Innovation and Digitization, through the National Core Program No. PN 19 06 02 03/2019, as well as by the Executive Unit for Financing Higher Education, Research, Development and Innovation (UEFISCDI), through the grants: TE 115/2020 and TE 25/2020.
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