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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2024-11-23 18:21 |
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Conference: Bucharest University Faculty of Physics 2022 Meeting
Section: Physics and Technology of Renewable and Alternative Energy Sources
Title:
Bionanostructured systems based on chitosan and selective polyphenolic extract
Authors:
Cornelia NICHITA (1,2), Mustafa K.H. ALHUSSAINY(1)
*
Affiliation:
1. University of Bucharest, ICUB, Faculty of Physics, CTT-3Nano-SAE Research Center, MG-38, 405 Atomistilor Street, 077125, Magurele, Romania,
2. National Institute for Chemical – Pharmaceutical Research and Development, 112 Vitan Avenue, 031299, Bucharest, Romania, cornelia@yahoo.com cornelia.nichita@unibuc.ro; cornelia@3nanosae.org
E-mail
cornelia.nichita@unibuc.ro; cornelia@3nanosae.org
Keywords:
Bionanostructured systems, Curcuma longa L. extract, antioxidant activity, encapsulation efficiency
Abstract:
Bionanostructured systems offer a number of features and benefits such as enhancement of solubility, bioavailability and pharmacological activity, protection from toxicity, sustained delivery and protection from physical and chemical degradation. The involvement of chitosan in obtaining the bionanostructured represent an option for controlled drug delivery. On the other hand, the application of nanotechnology in the use of plant extracts has revealed an advantageous strategy for herbal drugs, considering the benefits of nano encapsulation. This study focuses on a new bionanaostructure based on architectures of nano biopolymers, respectively chitosan and Curcuma longa L. extract, synthesized by ionotropic gelation with TPP crosslinking agent. In order to achieve this study were investigated by UV-VIS spectroscopy (Jasco, Japan, V-570 spectrophotometer) the total phenolic contents (TPC) expressed as gallic acid equivalent/g (mg/GAE g-1) using the Folin-Ciocalteu reagent, total flavonoid contents (TFC) expressed as rutin equivalent/g (mg/RE g-1), by aluminum chloride colorimetric assay and the caffeic acid derivatives content (CADC) expressed as mg caffeic acid equivalent/g dry extract (mg/CAg-1) by using Arnows’ reagent. Antioxidant activity of samples (Curcuma longa L. extract and bionanostructured systems) were evaluated by in vitro non cellular assays using the chemiluminescence technique, DPPH(2,2-diphenyl-1-picrylhydrazyl) free radical scavenging assay and ABTS (2,2′azinobis-(3-ethylbenzthiazoline-6- sulfonic acid) methods. The study included the evaluation of the encapsulation efficiency (EE%), as well as the investigation by dynamic light scattering technique for measuring the hydrodynamic size, the polydispersity index and the zeta potential.
Acknowledgement:
The support from the CTT 3 Nano-SAE Research Centre and the support from the Materials and Devices are thankfully acknowledged.
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