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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2024-11-23 17:41 |
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Conference: Bucharest University Faculty of Physics 2022 Meeting
Section: Biophysics; Medical Physics
Title:
Effect of “green” silver nanoparticles on urease activity
Authors:
Marcela-Elisabeta BĂRBÎNȚĂ-PĂTRAȘCU (1), Claudia CHILOM (1), Rafaela COCOSI-VARTOPEANU (1), Sorina IFTIMIE (1), Cornelia NICHITA (2,3), Irina ZGURA (4), Viorel IFTIMIE (5), Sanja PETROVIC (6)
Affiliation:
(1) University of Bucharest, Faculty of Physics, Department of Electricity, Solid-State Physics and Biophysics, Atomistilor Street 405, 077125 Măgurele, Ilfov, Romania; marcela.barbinta@unibuc.ro; elipatras@gmail.com; claudiafir@gmail.com; rafaela.fizmed@yahoo.com; sorina.iftimie@fizica.unibuc.ro;
(2) University of Bucharest, Faculty of Physics, CTT-3Nano-SAE Research Center, MG-38, 405 Atomistilor Street, 077125, Magurele, Romania, cornelia.nichita@unibuc.ro; cornelia@3nanosae.org
(3) National Institute for Chemical – Pharmaceutical Research and Development, 112 Vitan Avenue, 031299, Bucharest, Romania, cornelia@yahoo.com
(4) National Institute of Materials Physics, Atomistilor 405A, 077125 Magurele, Romania; irina.zgura@infim.ro
(5)Technological High School "Gh. Ruset Roznovanu", Roznov, Piatra Neamț, Romania; vioift@yahoo.com
(6) Department of Chemical Technology, Faculty of Technology, University of Nis, Bulevar Oslobodjenja 124, 16000 Leskovac, Serbia; milenkovic_sanja@yahoo.com
E-mail
marcela.barbinta@unibuc.ro; claudiafir@gmail.com
Keywords:
“green” silver nanoparticles; antioxidant activity; urease
Abstract:
Recent progress in “green” nanotechnology is trying to fight against many diseases, a special interest being given to silver nanoparticles.
Urease, a nickel-containing enzyme, has been reported to contribute to the pathogenesis of hepatic coma, encephalopathy, gastritis and gastric ulcer, and other diseases.
In this study, biogenic silver nanoparticles (bio-AgNPs) were “green” synthesized by using an aqueous extract of Mentha piperita L. leaves, and then examined against urease activity. The obtained AgNPs presented good physical stability (checked by zeta potential measurements) and high antioxidant activity (evaluated by chemiluminescence technique). Their size was estimated by DLS measurements. UV-Vis absorption and fluorescence emission spectroscopy were used to study the impact of bio-AgNPs on urease. The synthesized bio-AgNPs exhibited good urease inhibitory activity.
These findings could be exploited in the development of novel inhibitors of urease for biomedical applications.
References:
1. M. E. Barbinta-Patrascu, Biogenic nanosilver from Cornus mas fruits as multifunctional eco-friendly platform: “green” development and biophysical characterization, J. Optoelectron. Adv. M. 22(9-10), 523-528, 2020.
2. M. E. Barbinta-Patrascu, N. Badea, C. Ungureanu, D. Besliu, S. Antohe, Bioactive phyto-nanosilver particles “green” synthesized from Clary Sage, Burdock, Southernwood and Asparagus, Rom. Rep. Phys. 72(3), 606, 2020.
3. Barbinta-Patrascu, M. E., Ungureanu, C., Iordache, S. M., Iordache, A. M., Bunghez, I. R., Ghiurea, M., Badea, N., Fierascu, R. C., Stamatin, I. Eco-designed biohybrids based on liposomes, mint–nanosilver and carbon nanotubes for antioxidant and antimicrobial coating, Mat. Sci. Eng. C, 39, 177-185, 2014.
4. S. T. S. Hassan, E. Švajdlenka, Biological Evaluation and Molecular Docking of Protocatechuic Acid from Hibiscus sabdariffa L. as a Potent Urease Inhibitor by an ESI-MS Based Method, Molecules 22(10), 1696 (2017).
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