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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2024-11-23 17:50 |
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Conference: Bucharest University Faculty of Physics 2022 Meeting
Section: Biophysics; Medical Physics
Title:
Protein-based particles for biomedical applications
Authors:
Claudia CHILOM (1), Marcela-Elisabeta BĂRBÎNȚĂ-PĂTRAȘCU (1), Alexandra STAN (1), Teodora BURLANESCU (1,2), Mihaela-Bianca COTOI (1), Sorina IFTIMIE (1)
Affiliation:
(1) University of Bucharest, Faculty of Physics, Department of Electricity, Solid-State Physics and Biophysics, Atomistilor Street 405, 077125 Măgurele, Ilfov, Romania; claudiafir@gmail.com; marcela.barbinta@unibuc.ro; elipatras@gmail.com; stanalexandra550@gmail.com; teodora.burlanescu@infim.ro; cotoi.bianca94@gmail.com; sorina.iftimie@fizica.unibuc.ro
(2) National Institute of Materials Physics, Atomistilor 405A, 077125 Magurele, Romania; teodora.burlanescu33@gmail.com
E-mail
marcela.barbinta@unibuc.ro
Keywords:
bovine serum albumin nanoparticles; nanoprecipitation; ascorbic acid
Abstract:
Protein-based particles are one of the most important research topics in nanomedicine, being used especially as drug delivery systems. From the wide variety of proteins, albumins offer several advantages in biomedical applications, due to their availability, water solubility, innocuous degradation metabolites, biodegradability, biocompatibility, nontoxicity, they being components of the human and animal blood.
In this work, various types of bovine serum albumin nanoparticles (BSA-NPs), with or without ascorbic acid, were prepared via different nanoprecipitation methods. The obtained BSA-NPs were characterized by UV-Vis absorption and fluorescence spectroscopy. Their size and morphology were studied by Scanning Electron Microscopy (SEM). The stability in time of the synthesized BSA-NPs was spectrally monitored.These results could be exploited in the development of novel drug carrier systems to be used in biomedical field.
References:
1) Kianfar, E. (2021). Protein nanoparticles in drug delivery: animal proteins, plant proteins and protein cages, albumin nanoparticles. Journal of Nanobiotechnology, 19(1). doi:10.1186/s12951-021-00896-3.
2) Tarhini, M., Benlyamani, I., Hamdani, S., Agusti, G., Fessi, H., Greige-Gerges, H., Bentaher, A., Elaissari, A. (2018). Protein-Based Nanoparticle Preparation via Nanoprecipitation Method. Materials, 11(3), 394. doi:10.3390/ma11030394.
3) An, F.-F., & Zhang, X.-H. (2017). Strategies for Preparing Albumin-based Nanoparticles for Multifunctional Bioimaging and Drug Delivery. Theranostics, 7(15), 3667–3689. doi:10.7150/thno.19365.
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