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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2024-11-23 17:49 |
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Conference: Bucharest University Faculty of Physics 2022 Meeting
Section: Biophysics; Medical Physics
Title:
Pulsatory liposome – a two-stroke bionic biomicroengine
Authors:
Dumitru POPESCU 1*, Dumitru Petru IGA 2, Alin Gabriel POPESCU 3, Valentin I.R. NICULESCU 4
Affiliation:
(1)* Department of Mathematical Modeling in Life Sciences, Gh. Mihoc-Caius Iacob Institute of Mathematical Statistics and Applied Mathematics of Romanian Academy, 13 Septembrie Street, 050911, Bucharest, Romania. dghpopescu@gmail.com
(2) University of Bucharest, former C. I. Parhon, Bulevardul Regina Elisabeta Nr. 4-12, București 030018, Romania
(2) University of Oradea, Strada Universității nr. 1, Oradea 410087, Romania
(3) Faculty of Automatic Control and Computers, University Politehnica, Bucharest, 313 Splaiul Independentei, 060042, Romania
(4) Institut de Recherche et Development pour les Lasers, Plasma et Physique de la Radiation, Romania
E-mail
dghpopescu@gmail.com
Keywords:
Key words: Osmotic gradient, stretched vesicle, pulsatory vesicle, drug releasing biocontroller
Abstract:
In this work, we have considered the problem of a pulsatory lipid vesicle. Under positive osmotic stress a giant lipid vesicle swells up to a critical diameter, when suddenly a transbilayer pore appears if the swelling process is slowly enough. A part of the intracellular material comes out of the cell through this transmembrane pore and the liposome membrane relaxes and finally, it recovers. The pore increases in the first part of its evolution, then decreases, and finally it closes. The both simultaneous dynamics processes described above start again and so on. The vesicle evolution is a cyclic process and the vesicle becomes a pulsatory one. Here we will obtain the differential equations of both the vesicle and the pore dynamics. Also, we will analyse the characteristic parameters of the periodic process (swelling time, pore lifetime, number of cycles, the duration of vesicle activity, material quantity leaked out during a cycle). Also, we present the conditions to programme a n-cycles working vesicle.
References:
REFERENCES
1. Popescu, D. The Pulsatory Lipid Vesicle Dynamics under Osmotic Stress; Lambert Academic Publishing and AV Academikerverlag: Saarbruecken, Germany, 2012.
2. Popescu, D., Popescu, A. G. The working of a pulsatory liposome. J. Theoret. Biol. 2008, 254 515–519.
3. Movileanu, L.; Popescu, D.; Ion, S.; Popescu, A. I. Transbilayer pores induced by thickness fluctuations. Bull. Math. Biol. 2006, 68, 1231−1255
4. Popescu, A. I. Tratat de bionică. Perspectivă generală cu explicații biofizice, Publishing House of Bucharest University (in press) 2022
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