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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2024-11-23 18:11 |
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Conference: Bucharest University Faculty of Physics 2022 Meeting
Section: Biophysics; Medical Physics
Title:
Adaptive radiotherapy in cervical cancer
Authors:
Bianca Anamaria BADEA (1), Claudia CHILOM (1), Cristian CIOABĂ (2)
*
Affiliation:
1) University of Bucharest, Faculty of Physics, Department of Electricity, Solid-State Physics and Biophysics, Atomistilor Street 405, 077125 Măgurele, Ilfov, Romania;
2) "Sfântul Nicolae” Medical Center, Pitești, Argeș Romania
E-mail
biancabadea@ymail.com
Keywords:
cervical cancer; therapy; adaptive radiotherapy;
Abstract:
Cervical cancer is a diagnosis present in more than half a million women each year (by 2020, ~ 600,000 women have been reported). This disease leads to over 300,000 deaths each year, staying in the top 4 ranking of women cancer. In most cases, the cause of the disease is human papilloma virus (HPV), smoking, or immune system dysfunction. 90 % of this disease occurs in low-income and middle countries, while in developed countries the incidence and mortality of cervical cancer has been significantly reduced.
Adaptive radiotherapy helps cancer treatment, with the primary goal being to deliver individualized radiation therapy, based on the inclusion of feedback on anatomical and biological changes during treatment planning and optimization.
ART is trying to change the initial parameters of the treatment plan so that it can compensate for changes during treatment. The changes can be anatomical, due to migration or movement of the tumor, but also the weight loss of the patient. This type of radiotherapy uses multimodal imaging and plan optimization in order to compensate for the above changes. ART radiotherapy can be used at different times of treatment, in order to increase dependence on automatic processes. This type of therapy offers a major advantage for cervical cancer due to the complex and varied movement of the target of the cervix during radiotherapy.
In this study, the difference between dose delivered at the beginning of the treatment and the way it modifies during the radiotherapy therapy is explained. Also, this study contains the way the planning evolved during the therapy and what would happen if the treatment planning had not been improved.
References:
«International Agency for Research on Cancer. Available: https://gco.iarc.fr/.
Paul A. C., Anjua J., Ana O., Lynette D., Cervical cancer, The Lancet, 393, 110167, 169-182, 2019
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