| |
 |
UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2024-11-23 17:59 |
 |
|
|
|
Conference: Bucharest University Faculty of Physics 2022 Meeting
Section: Biophysics; Medical Physics
Title:
Quality control in quantitative SPECT/CT imaging: concepts, requirements, methodes
Authors:
Ilie Andrei NECSOIU (1,2), Cristina PETROIU (1), Alexandru JIPA (2)
Affiliation:
1) Oncology Institute of Bucharest „Professor Doctor Alexandru Trestioreanu”
2) Faculty of Physics, University of Bucharest
E-mail
necsoiu.andrei98@yahoo.com
Keywords:
Nuclear medicine, quantitative SPECT/CT, quality control, phantoms, SUV
Abstract:
Nuclear medicine imaging is an exquisitely sensitive method of assessing and quantifying physiological processes in vivo. Historically, nuclear medicine quantification has progressed from simple thyroid uptake measurements to present kinetic and standard uptake value (SUV) analysis using PET. More recently, single photon emission computed tomography (SPECT) quantification in terms of kBq/mL has become more common - predominantly because of the needs of internal dosimetry for radionuclide therapy. Quantitative SPECT/CT imaging allows the usage of a extensive range of radiopharmaceuticals in various cancer studies and other clinical applications. While the concept of quantitative SPECT/CT has existed for years, SPECT/CT systems are not intrinsically quantitative; their means for measuring activity concentration are limited without additional efforts such as complex manual calibrations.
Performing acquisitions using SPECT/CT systems that meet the requirements of periodic quality control tests and properly calibrated, according to NEMA/IAEA/AAPM international guidelines, are essential for obtaining accurate quantitative results. In quantitative SPECT imaging, conversion of pixel values from counts to radioactivity concentration per unit volume (for example, Bq/mL) requires measuring a conversion factor, often referred to as system sensitivity. This factor should be measured for each combination of collimator and radioisotope, in a cross calibration procedure (cps/MBq) units.
We also tested the quantitative accuracy of the SPECT/CT system for 99mTc in a simple configuration (phantom - NEMA NU-2), evaluating background calibration factor, recovery coefficient, the accuracy of measurements, coefficient of variation for image noise, total activity deviation, and contrast recovery.
References:
1. INTERNATIONAL ATOMIC ENERGY AGENCY, Quantitative Nuclear Medicine Imaging: Concepts, Requirements and Methods, IAEA Human Health Reports No. 9, IAEA, Vienna (2014)
2. Kurkowska, S., Birkenfeld, B., & Piwowarska-Bilska, H. (2021). Physical quantities useful for quality control of quantitative SPECT/CT imaging. Nuclear medicine review. Central & Eastern Europe, 24 2, 93-98.
3. Gnesin, S., Ferreira, P., Malterre, J., Laub, P., Prior, J.O., & Verdun, F.R. (2016). Phantom Validation of Tc-99m Absolute Quantification in a SPECT/CT Commercial Device. Computational and Mathematical Methods in Medicine
|
|
|
|