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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2024-11-23 17:38 |
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Conference: Bucharest University Faculty of Physics 2022 Meeting
Section: Polymer Physics
Title:
Poly(N-isopropylacrylamide-butylacrylate) Copolymer coatings obtained by MAPLE for bioapplications
Authors:
Nicoleta-Luminita DUMITRESCU(1), Anca BONCIU(2), Madalina ICRIVERZI(3), Paula FLORIAN(3), Antoniu MOLDOVAN(1), Simona NISTORESCU(2), Anca ROSEANU(3), Laurentiu RUSEN(1), Valentina MARASCU(1), Valentina DINCA(2)
*
Affiliation:
1) INFLPR, 409 Atomistilor Street, Magurele, RO-077125, ROMANIA
2) INFLPR,FOTOPLASMAT Department, 409 Atomistilor Street, Magurele, RO-077125, ROMANIA
3) IBAR, Ligand-Receptor Interactions Department, Institute of Biochemistry of the Romanian Academy,060031,ROMANIA
E-mail
valentina.dinca@inflpr.ro
Keywords:
smart hybrid platform; pNIPAM-co-BA; MAPLE
Abstract:
New smart hybrid platform targeting stimuli responsiveness based on
innovative and complex hybrid coatings (pNIPAM-co-BA with/without single active bio-compound (i.e., antimicrobial peptides and proteins) and their conjugates were obtained by MAPLE. Different laser fluences values were used for different solvents to obtain the desired surface for cell-bio interface applications. AFM and SEM methods were used to characterize the surfaces obtained, in order to correlate to biological response. Chemical characteristics of the coatings were evaluated by Fourier-transform-IR spectroscopy. Tumoral cell viability and morphology were analyzed using colorimetric (MTS) and SEM methods. Biological assays proved morphological and proliferation changes were conditioned by the cell line and type of coating preparation.
Acknowledgement:
Acknowledgement: This work was supported by by a grant from the Romanian Ministry of Education and Research, CCCDI-UEFISCDI, project number PN-III-P2-2.1-PED-2019-2695, within PNCDI III
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