UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS

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2024-11-23 17:46
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Conference: Bucharest University Faculty of Physics 2023 Meeting


Section: Biophysics; Medical Physics


Title:
Teaching Biophysics II. Biophysical approach of transport through cellular membranes


Authors:
Aurel I. POPESCU, Claudia Gabriela CHILOM


Affiliation:
University of Bucharest, Faculty of Physics, Department of Electricity, Solid-State Physics and Biophysics


E-mail
prof.aurel.popescu@gmail.com


Keywords:
Active transport, ionic pumps, ATP-synthase, passive transport, simple diffusion, facilitated diffusion, carriers, ionic channels, pore formers, vesicular transport


Abstract:
Cellular metabolism implies a permanent transport through membranes of a great diversity of particles (e.g., ions, molecules, macromolecules, protein vesicles, etc.) in and out of the cells. The transport phenomena can be classified as passive (along the concentration gradients, driven solely by thermal agitation) or active (against the concentration gradients, driven by an energy supply) and selective (i.e., through specific pathways) or non selective through membrane lipid bilayers. This paper will describe in an accessible manner and classify all the types of membrane transport from a biophysical point of view along with their crucial roles in normal cellular functioning.


References:

A. I. Popescu, C. G. Chilom, Teaching biophysics I. The specific interactions: the s ine qua non processes of life, Romanian Report in Physics (2023) (accepted)

V. Raicu, A. Popescu, Integrated Molecular and Cellular Biophysics, Edition Springer (2008).

A. I. Popescu, Biophysics. Current Status and Future Trends, The Publishing House of the Romanian Academy (2016).

Z. Ye, Y. Lu, T. Wu, The impact of ATP-binding cassette transporters on metabolic diseases, Nutrition & Metabolism, 17, 61, 1-14, 2020

R. X. Gu, V. Corradi, G. Singh, H. G. Choudhury, K. Beis, D. P. Tieleman, Conformational changes of the antibacterial peptide ATP binding cassette transporter McjD revealed by molecular dynamics simulations, Biochemistry, 54, 5989-98, 2015