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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2024-11-23 17:46 |
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Conference: Bucharest University Faculty of Physics 2023 Meeting
Section: Biophysics; Medical Physics
Title:
The photodegradation processes of acetyl salycilic acid
Authors:
Mădălina-Georgiana CHIVU(1,2), Monica DĂESCU(1), Mihaela BAIBARAC(1), Marcela-Elisabeta BĂRBÎNȚĂ-PĂTRAȘCU(2)
Affiliation:
1) Laboratory of Optical Processes in Nanostructured Materials, National Institute of Materials Physics, Atomistilor Street 405A, POB MG 7, 077125 Bucharest, Romania
2) University of Bucharest, Faculty of Physics, Department of Electricity, Solid-State Physics and Biophysics, Atomistilor Street 405, 077125 Măgurele, Ilfov, Romania
E-mail
chivugeorgiana79@yahoo.com
Keywords:
acetyl salycilic acid, photodegradation, UV irradiation, spectral investigation
Abstract:
This research work presents the spectral investigation (Raman, FTIR, fotoluminescence and UV-VIS spectroscopy) of the photodegradation process of acetyl salycilic acid (ASA) in the presence of H2O2. This study has a high importance in the biomedical field, because ASA contains a reactive acetyl group which can oxidize easily, and also carboxylic and ester functional groups which are highly vulnerable to hydrolysis under various hydrolytic conditions. The purpose of this study is to determine the ASA behaviour in the absence and in the presence of excipients in aqueous solutions containing H2O2.
According to the UV-VIS spectra, after 130 minutes of irradiation of ASA in the presence of H2O2, a bathochromic shift of the maximum absorption band from 290 nm to 298 nm was observed. The photoluminescence spectra show that the irradiation of ASA in the presence of H2O2 leads to a decrease in the maximum intensity of the ASA band from 2.75 ∙10^3 counts/sec to 2.65∙10^3 counts/sec, simultaneously with the shift of the maximum of the PL band from 366 nm to 369 nm. Exposure to UV light of ASA solutions containing H2O2 resulted in an additional shift of the maximum of the PL band to 331 nm, simultaneously with the increase in intensity of the PL band situated at 397 nm from 2.25∙10^3 counts/sec to 3.00 ∙10^3 counts/sec.
References:
Monica Dăescu, Miruna Ioță, Constantin Serbschi, Alina C. Ion, Mihaela Baibarac The Influence of UV Light on Photodegradation of Acetylsalicylic Acid, Molecules, 2021, 22, 4046
Lefrant S, Baibarac M, Baltog I. Raman and FTIR spectroscopy as valuable tools for the characterization of polymer and carbon nanotube based composites. Journal of Materials Chemistry, 2009, 19, 5690.
M.Dhavacthira, C. Muthuselvi, S. Pandiarajan, Growth and Characterization of Aspirin Crystal in the Phosphoric acid Medium, Journal of Chemical and Pharmaceutical Research, 2016, 8(5):804-814
Acknowledgement:
POC 58/2016 (Competitiveness Operational Program 2014-2020)
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