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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2024-11-23 17:56 |
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Conference: Bucharest University Faculty of Physics 2023 Meeting
Section: Solid State Physics and Materials Science, Optics, Spectroscopy, Plasma and Lasers
Title:
Degradation of losartan potassium highlighted by correlated studies of photoluminescence and infrared absorption spectroscopy
Authors:
Mirela PARASCHIV (1,2), Ion SMARANDA (1), Irina ZGURA (1), Paul GANEA (1), Madalina CHIVU (1), Bogdan CHIRICUTA, Mihaela BAIBARAC (1)
*
Affiliation:
1) National Institute of Materials Physics, Atomistilor street 405A, P.O. Box MG-7, 077125 Bucharest, Romania
2)Faculty of Physics, University of Bucharest, P.O. Box MG-11, 077125 Bucharest, Romania
E-mail
mirela.cristea@infim.ro
Keywords:
Photoluminescence, FTIR spectroscopy, Degradation of Losartan Potassium
Abstract:
In this communication, the results reported by correlated studies of FTIR spectroscopy and photoluminescence present the degradation of losartan potassium (LP), in absence and in presence of the excipients, induced by the UV light, the acid character of tampon phosphate (TP) and the alkaline medium. The photoluminescence (PL) spectra of LP of the drug marked under the name Lorista (LO) is characterized by intense emission bands, peaked at 378 nm and 380 nm, respectively, accompanied by low intensity bands having maxima at 450-460 nm [1]. The photodegradation process of LO in solid state is highlighted by a decrease in the intensity of the PL band located at 380 nm, variation which origins both in the adsorption of water vapors from air and the interaction of LP with the excipients [1, 2, 3, 4]. The influence of acide and alkaline medium, respectively, on the LO degradation is analyzed using tampon phosphate (TP) and NaOH solutions. The intensity diminution of the PL spectra of NaOH-reacted LP and LO is the result of the formation of the photodegradation product C16H15N5O2 [1]. With the help of FTIR spectroscopy we have highlighted the appearance of the IR band at 1740 cm-1 [1, 5, 6] and the absorbance increase of the IR band at 1423 cm-1 [1, 7, 8]. In our opinion, the photodegradation product contains the C=O and C-OH functional groups.
References:
1)M. Paraschiv, I. Smaranda, I. Zgura, P. Ganea, M. Chivu, B. Chiricuta, M. BaibaracDegradation of losartan potassium highlighted by correlated studies of photoluminescence, infrared absorption spectroscopy and dielectric spectroscopy. Pharmaceutics, 14(11), 2419, 2022.
2)J. Yang, H. Fang, Y. Gao. Effect of water adsorption on the photoluminescence of silicon quantum dots, Journal of Physical Chemistry Letters, 17, 1788-1793, 2016.
3)T. Katsumata, T. Suzuki, H. Aaizawa. Matashige. Photoluminescence evaluation of cereals for a quality control application, Journal of Food Engineering, 78, 588-590, 2007.
4)J. Jiang, S. Lu, M. Liu, C. Li, Y. Zhang, T.B. Yu, L. Yang, Y. Shen, Q. Zhou. Tunable photoluminescence properties of microcrystalline cellulose with gradually changing crystallinity and crystal form, Macromolecular Rapid Communication, 2100321, 1-6, 2021.
5)L. Zhang, X. Li, S. Zhang, Q. Gao, Q. Lu, R. Peng, P. Xu, H. Shang, Y. Yuan, H. Zou. Micro-FTIR combined with curve fitting method to study cellulose crystallinity of developing cotton fibers, Analytical and Bioanalytical Chemistry 2021, 413, 1313-1320.
6)M. Ibrahim, O. Osman. Spectroscopic Analyses of cellulose: Fourier Transform Infrared and Molecular Modelling study, Journal of Computational and Theoretical Nanoscience, 6, 1054-1058, 2009.
7)S. Pavlovic, P.R.C. Brandao. Adsorption of starch, amylose, amylopectin and glucose monomer and their effect on the flotation of hematite and quartz, Minerals Engineering, 16, 1117-1122, 2003.
8)D. Kohli, S. Garg, A.K. Jana. Synthesis of cross-linked starch based polymers for sorption of organic pollutants from aqueous solutions, Indian Chemical Engineer, 54, 210-222, 2012.
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