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UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS Guest
2024-11-23 18:27 |
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Conference: Bucharest University Faculty of Physics 2023 Meeting
Section: Biophysics; Medical Physics
Title:
Design and characterization of albumin nanoparticles
Authors:
Diana-Lavinia STAN(1), Marcela-Elisabeta BĂRBÎNȚĂ-PĂTRAȘCU(1), Sorina IFTIMIE(1), Nicoleta CAZACU(1),Sorina IFTIMIE(1), Andreea COSTAS(2), Adriana Elena BĂLAN(1), Claudia Gabriela CHILOM(1)
Andreea COSTAS (2), Adriana Elena BALAN (1), Claudia Gabriela CHILOM (1)
Affiliation:
1) University of Bucharest, Faculty of Physics, 405 Atomistilor Street, P.O. Box MG-11, 077125 Magurele, Romania
2) National Institute of Materials Physics, 077125 Magurele, Romania
E-mail
diana.stan3@s.unibuc.ro; marcela.barbinta@unibuc.ro; sorina.iftimie@fizica.unibuc.ro; nicoleta.sandu@drd.unibuc.ro; adriana.balan@unibuc.ro; claudia-gabriela.chilom@unibuc.ro; andreea.costas@infim.ro
Keywords:
Albumin nanoparticles, desolvation
Abstract:
The use of albumin nanoparticles as precisely targeted drug delivery systems is one of the directions increasingly addressed in nanomedicine. These nanoparticles offer the advantage of biocompatibility and biodegradability, making them suitable for the delivery of drugs or molecules with antioxidant or anticancer activity. In this study, the desolvation method was used to prepare bovine serum albumin nanoparticles (BSA NPs). Their morphology and dimensions were examined by scanning electron microscopy (SEM) and atomic force microscopy (AFM), and their stability over time was evaluated using UV-Visible absorption spectroscopy. The experimental results showed that BSA NPs have a spherical shape, with a smooth surface. Their average diameter is around 200 nm, and the stability over time is relatively good. Such large NPs may have limited ability to passively diffuse into tissues, but they may still be able to actively target specific cells or tissues. For example, BSA NPs could be designed to remain at the site of administration, rather than needing to travel into the body.
Acknowledgement:
This research was funded by the Project No. 582PED⁄2022, New hybrid protein nanostructures for targeting specific in colon tumor cells (Prot-Col-Target), PN-III-P2-2.1-PED-2021-1323/01.08.2022.
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